Disease relevance of fiu

• Expression of the A. actinomycetemcomitans fur gene product repressed fiu expression and siderophore production in E. coli [1].

High impact information on fiu

• The fusion was in fiu (ferric ion uptake), encoding an iron-regulated outer membrane protein (IROMP) controlled via four overlapping ferric uptake regulator (Fur) boxes in the sigma70 promoter region [2].
• Both tonB and cir fiu double mutants of E. coli had greatly decreased susceptibility to BMS-180680 [3].
• E0702 was shown to enhance the uptake of radioactive ferric iron into wild-type cells but not into cir fiu double mutants [4].
• Fur(AF) represses gene expression from E. coli Fur-responsive promoters fiu and fhuF when expressed at high protein levels [5].

Other interactions of fiu

• Mutants devoid of all six iron-regulated outer membrane proteins were no more resistant to the probe compounds than fiu cir or tonB strains [6].

References