The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

fliK  -  flagellar hook-length control protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1941, JW1927, flaE
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of fliK


High impact information on fliK

  • The transcript start site in front of flaE was determined and the -10 region conforms to the E. coli sigma 28 promoter consensus sequence [2].
  • The entire promoter region and an upstream consensus sequence that might be a regulatory element for the flaY gene lies within the carboxyl-terminal coding sequence of the flaE gene [2].
  • We have determined the DNA sequence of the fliK gene in both bacterial species [1].
  • By correlating various deletions and insertions in the flaB operon with the ability to complement specific flagellar mutants and code for polypeptides, we made the following gene product assignments: flaB 1, 60 kilodaltons; flaB 11, 38 kilodaltons; flaB111, 28 kilodaltons; flaC, 56 kilodaltons; fla0, 16 kilodaltons; and flaE, 54 kilodaltons [3].

Analytical, diagnostic and therapeutic context of fliK

  • Reverse transcription-polymerase chain reaction (RT-PCR) analysis revealed that the genes flaE to flaK are transcribed into one polycistronic message [4].


  1. Characterization of the flagellar hook length control protein fliK of Salmonella typhimurium and Escherichia coli. Kawagishi, I., Homma, M., Williams, A.W., Macnab, R.M. J. Bacteriol. (1996) [Pubmed]
  2. Temporal regulation and overlap organization of two Caulobacter flagellar genes. Kaplan, J.B., Dingwall, A., Bryan, R., Champer, R., Shapiro, L. J. Mol. Biol. (1989) [Pubmed]
  3. Identification of Escherichia coli region III flagellar gene products and description of two new flagellar genes. Bartlett, D.H., Matsumura, P. J. Bacteriol. (1984) [Pubmed]
  4. The fla gene cluster is involved in the biogenesis of flagella in Halobacterium salinarum. Patenge, N., Berendes, A., Engelhardt, H., Schuster, S.C., Oesterhelt, D. Mol. Microbiol. (2001) [Pubmed]
WikiGenes - Universities