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Gene Review

argS  -  arginyl-tRNA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1877, JW1865, lov
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Disease relevance of argS

  • Expression of the argS gene in B. lactofermentum and E. coli resulted in an increase in aminoacyl-tRNA synthetase activity, correlated with the presence in sodium dodecyl sulfate-polyacrylamide gels of a clear protein band that corresponds to this enzyme [1].
  • The Brevibacterium lactofermentum argS gene, which encodes an arginyl-tRNA synthetase, was identified in the upstream region of the lysA gene [1].

High impact information on argS


Chemical compound and disease context of argS


Anatomical context of argS

  • The allele specificity of the suppression suggests that the lov gene product may interact directly with the ribosomes [2].

Associations of argS with chemical compounds

  • The lov gene product thus seems to define a link between PBP2 (the mecillinam target) and the ribosomes; we propose that this link is involved in transmitting information on the growth rate (ribosome concentration) to the peptidoglycan synthesizing apparatus [2].
  • This finding emphasizes the necessity of using pure arginyl-tRNA synthetase in order to study the possible regulatory involvement of this enzyme in the control of the arginine regulon in vitro [4].
  • We may conclude that the substitution of 4-fluorotryptophan in arginyl-tRNA synthetase had no substantial effect on the structure and function of the enzyme [5].

Other interactions of argS


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