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Gene Review:

mtfA - anti-repressor for DgsA(Mlc)

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1972, JW1958, yeeI

Becker, A.K. et al.

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Disease relevance of mtfA

One class of mutations was located in the open reading frame yeeI at 44.1 min on the E. coli K-12 chromosome [1].

High impact information on mtfA

The yeeI mutants exhibited increased generation times during growth on glucose, reduced transport of methyl-alpha-d-glucopyranoside, a substrate of EIICB(Glc), reduced induction of a ptsG-lacZ operon fusion, and reduced catabolite repression in lactose/glucose diauxic growth experiments [1].
The effect of a yeeI mutation could be suppressed by introducing a dgsA deletion, implying that the two proteins belong to the same signal transduction pathway and that Mlc is epistatic to YeeI [1].

References

YeeI, a novel protein involved in modulation of the activity of the glucose-phosphotransferase system in Escherichia coli K-12. Becker, A.K., Zeppenfeld, T., Staab, A., Seitz, S., Boos, W., Morita, T., Aiba, H., Mahr, K., Titgemeyer, F., Jahreis, K. J. Bacteriol. (2006) [Pubmed]

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