Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

alpA - CP4-57 prophage; DNA-binding...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2620, JW2604

Trempy, J.E. et al., Kirby, J.E. et al.

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Disease relevance of alpA

The Escherichia coli K-12 alpA gene product, when overproduced from a multicopy plasmid, leads to suppression of the capsule overproduction and UV sensitivity phenotypes of cells mutant for the Lon ATP-dependent protease [1].

High impact information on alpA

The Alp protease activity is detected in cells after introduction of plasmids carrying the alpA gene, which encodes an open reading frame of 70 amino acids [2].
We have used Tn10 and lambda placMu mutagenesis to identify a chromosomal locus, slpA, that is required for alpA+ suppression of delta lon [2].
We have previously found that plasmids carrying the Escherichia coli alp gene (now to be called alpA) suppress two phenotypes of a delta lon protease mutant, overproduction of capsular polysaccharide and sensitivity to UV light [2].

References

Excision of a P4-like cryptic prophage leads to Alp protease expression in Escherichia coli. Kirby, J.E., Trempy, J.E., Gottesman, S. J. Bacteriol. (1994) [Pubmed]
Alp suppression of Lon: dependence on the slpA gene. Trempy, J.E., Kirby, J.E., Gottesman, S. J. Bacteriol. (1994) [Pubmed]

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