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Gene Review

lon  -  DNA-binding ATP-dependent protease La

Escherichia coli O157:H7 str. EDL933

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Disease relevance of lon


High impact information on lon

  • Five different lon mutations, not related to the Mar phenotype, were also found in 12 of the 13 mutants [2].
  • Role for tandem duplication and lon protease in AcrAB-TolC- dependent multiple antibiotic resistance (Mar) in an Escherichia coli mutant without mutations in marRAB or acrRAB [3].
  • We have used Tn10 and lambda placMu mutagenesis to identify a chromosomal locus, slpA, that is required for alpA+ suppression of delta lon [1].
  • Moreover, 2-D gel analysis revealed that the expression level of some scavenger proteins marks the lon mutant as being in a situation similar to oxidative stress [4].

Biological context of lon

  • Suppression of these lon phenotypes is most likely explained by the increased degradation of the Lon substrates responsible for these phenotypes [1].

Analytical, diagnostic and therapeutic context of lon

  • Our RT-PCR analysis revealed an elevation of expression of the oxyS gene in the lon mutant [4].
  • The results of Western blotting detected a decrease in the protein expression levels of BtuB and OmpF involved in colicin translocation in the lon mutant [4].


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