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Gene Review:

napF - ferredoxin-type protein, role in electron...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2200, JW2196, yojG

McNicholas, P.M. et al., Nilavongse, A. et al.

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High impact information on napF

Utilizing a napF-lacZ operon fusion, we demonstrate that napF gene expression is impaired in strain defective for the molybdate-responsive ModE transcription factor [1].
The upstream ModE regulatory site functions to override nitrate control of napF gene expression when the essential enzyme component, molybdate, is limiting in the cell environment [1].
The nap operon encoding this nitrate reductase comprises seven genes including a gene, napF, that encodes a putative cytoplasmic iron-sulphur protein of uncertain subcellular location and function [2].

Associations of napF with chemical compounds

These findings indicate the involvement of an additional transcription factor to help coordinate nitrate- and molybdate-dependent napF expression by the Fnr, NarP, NarL, and ModE proteins [1].

References

The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability. McNicholas, P.M., Gunsalus, R.P. J. Bacteriol. (2002) [Pubmed]
The NapF protein of the Escherichia coli periplasmic nitrate reductase system: demonstration of a cytoplasmic location and interaction with the catalytic subunit, NapA. Nilavongse, A., Brondijk, T.H., Overton, T.W., Richardson, D.J., Leach, E.R., Cole, J.A. Microbiology (Reading, Engl.) (2006) [Pubmed]

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