Disease relevance of ptrA

• Analysis of the regulatory region of the protease III (ptr) gene of Escherichia coli K-12 [1].

High impact information on ptrA

• At its 3' end, the ptr gene overlaps the start of the recB coding sequence by 8 bases, suggesting that these genes may form part of an operon [2].
• Complete nucleotide sequence of the Escherichia coli ptr gene encoding protease III [2].
• The nucleotide sequence of a 3120 bp region of the E. coli chromosome that includes the entire ptr gene has been determined [2].
• The influence of extracytoplasmic proteases on the resistance of Escherichia coli to the antimicrobial peptide protamine was investigated by testing strains with deletions in the protease genes degP, ptr, and ompT [3].
• The nucleotide sequence of a 1167-bp EcoRV-ClaI fragment of chromosomal DNA containing the promoter region and 885 bp of the ptr coding sequence has been determined [1].

Biological context of ptrA

• Although recC, ptr, and recB were physically closely linked and transcribed in the same direction, they do not appear to constitute an operon [4].

References