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Gene Review

recC  -  exonuclease V (RecBCD complex), gamma chain

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2818, JW2790
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Disease relevance of recC

  • Attempts to isolate conditionally lethal recB and recC mutations of Escherichia coli K-12 by P1 localized mutagenesis led to the identification of the structural gene for an essential membrane protein [1].
  • The old (overcoming lysogenization defect) gene product of bacteriophage P2 kills Escherichia coli recB and recC mutants and interferes with phage lambda growth [Sironi et al., Virology 46 (1971) 387-396; Lindahl et al., Proc. Natl. Acad. Sci. USA 66 (1970) 587-594] [2].

High impact information on recC

  • Complete nucleotide sequence of the Escherichia coli recC gene and of the thyA-recC intergenic region [3].
  • We previously demonstrated that initiation of iSDR requires the products of genes, such as recA, recB and recC, that are involved in the early stages of homologous recombination [4].
  • However, recombination can proceed efficiently without RecBCD in recB or recC strains carrying additional mutations in both the sbcB and sbcC genes [5].
  • The radB101 and recN262 mutations showed essentially identical phenotypes when compared in isogenic Escherichia coli strains for their effects on gamma and UV radiation survival and on conjugal recombination in a uvrA recB recC sbcB sbcC strain [6].
  • The interspecific recombination is dependent on the RecABCD pathway: it was abolished in a recA mutant and decreased approximately 10(3)-fold in a recC mutant [7].

Biological context of recC


Other interactions of recC

  • Mutations in the genes recB or recC, encoding two subunits of the enzyme, reduce the frequency of many types of recombinational events [9].


  1. Identification and genetic mapping of the structural gene for an essential Escherichia coli membrane protein. Williams, M.G., Fortson, M., Dykstra, C.C., Jensen, P., Kushner, S.R. J. Bacteriol. (1989) [Pubmed]
  2. The P2 phage old gene: sequence, transcription and translational control. Haggård-Ljungquist, E., Barreiro, V., Calendar, R., Kurnit, D.M., Cheng, H. Gene (1989) [Pubmed]
  3. Complete nucleotide sequence of the Escherichia coli recC gene and of the thyA-recC intergenic region. Finch, P.W., Wilson, R.E., Brown, K., Hickson, I.D., Tomkinson, A.E., Emmerson, P.T. Nucleic Acids Res. (1986) [Pubmed]
  4. Roles of ruvA, ruvC and recG gene functions in normal and DNA damage-inducible replication of the Escherichia coli chromosome. Asai, T., Kogoma, T. Genetics (1994) [Pubmed]
  5. Linkage distortion following conjugational transfer of sbcC+ to recBC sbcBC strains of Escherichia coli. Lloyd, R.G. J. Bacteriol. (1991) [Pubmed]
  6. Genetic and phenotypic analyses indicating occurrence of the recN262 and radB101 mutations at the same locus in Escherichia coli. Sargentini, N.J., Smith, K.C. J. Bacteriol. (1988) [Pubmed]
  7. Interspecific recombination between Escherichia coli and Salmonella typhimurium occurs by the RecABCD pathway. Rayssiguier, C., Dohet, C., Radman, M. Biochimie (1991) [Pubmed]
  8. Synthesis of linear plasmid multimers in Escherichia coli K-12. Cohen, A., Clark, A.J. J. Bacteriol. (1986) [Pubmed]
  9. The genetic dependence of recombination in recD mutants of Escherichia coli. Lovett, S.T., Luisi-DeLuca, C., Kolodner, R.D. Genetics (1988) [Pubmed]
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