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Gene Review

tsaD  -  tRNA(ANN) t(6)A37 threonylcarbamoyladenosi...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3054, JW3036, gcp, ygjD
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Disease relevance of ygjD

  • We show that ygjD and its ortholog ydiE are essential in E. coli and B. subtilis, respectively [1].
  • The gene ygjD, encoding a sialoglycoprotease, was eliminated from a minimal genome computationally derived from a comparison of the Haemophilus influenzae and M. genitalium genomes [1].
  • The putative glycoprotease encoded by the gcp gene might be responsible for the degradation of cyanophycin in Synechocystis [2].
  • We performed cDNA and genomic cloning, sequencing and promoter analysis of the putative human O-sialoglycoprotein endopeptidase gene OSGEP (a homologue of gcp, a Pasteurella haemolytica A1 glycoprotease) [3].

High impact information on ygjD

  • This deletion affected four open reading frames: a gcp gene homolog, the psaFJ genes, and an unknown gene [2].
  • When the cloned gcp gene is expressed in Escherichia coli, the recombinant glycoprotease (rGcp) is exported to the periplasm but does not exhibit enzymatic activity [4].
  • The O-sialoglycoprotein endopeptidase (glycoprotease, Gcp) is secreted by Pasteurella haemolytica A1, a Gram-negative pathogen associated with bovine pneumonic pasteurellosis [4].


  1. A genome-based approach for the identification of essential bacterial genes. Arigoni, F., Talabot, F., Peitsch, M., Edgerton, M.D., Meldrum, E., Allet, E., Fish, R., Jamotte, T., Curchod, M.L., Loferer, H. Nat. Biotechnol. (1998) [Pubmed]
  2. Mutation of a gene encoding a putative glycoprotease leads to reduced salt tolerance, altered pigmentation, and cyanophycin accumulation in the cyanobacterium Synechocystis sp. strain PCC 6803. Zuther, E., Schubert, H., Hagemann, M. J. Bacteriol. (1998) [Pubmed]
  3. Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes. Seki, Y., Ikeda, S., Kiyohara, H., Ayabe, H., Seki, T., Matsui, H. Gene (2002) [Pubmed]
  4. Comparison of the recombinant and authentic forms of the Pasteurella haemolytica A1 glycoprotease. Watt, M.A., Mellors, A., Lo, R.Y. FEMS Microbiol. Lett. (1997) [Pubmed]
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