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Gene Review

cytR  -  Anti-activator for CytR-CRP nucleoside...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3926, JW3905
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Disease relevance of cytR


High impact information on cytR

  • The gene maps to 88.7 minutes on the chromosome adjacent to the cytR locus [3].
  • Footprinting studies with purified CAP protein revealed two CAP binding sites upstream of the cytR promoter [1].
  • A chromosomal cytR-lacZ+ operon fusion was isolated and used to study the regulation of cytR [1].
  • DNA sequence analysis of the cytR* mutation revealed a G-C to an A-T base pair transition at position -34 bp relative to the translational initiation site of cytR [1].
  • In crude cell extracts hSOD expression levels were found to be high in hosts possessing no deoR or cytR repressors [4].

Analytical, diagnostic and therapeutic context of cytR


  1. Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex. Gerlach, P., Valentin-Hansen, P., Bremer, E. Mol. Microbiol. (1990) [Pubmed]
  2. Peh production, flagellum synthesis, and virulence reduced in Erwinia carotovora subsp. carotovora by mutation in a homologue of cytR. Matsumoto, H., Muroi, H., Umehara, M., Yoshitake, Y., Tsuyumu, S. Mol. Plant Microbe Interact. (2003) [Pubmed]
  3. The priA gene encoding the primosomal replicative n' protein of Escherichia coli. Lee, E.H., Masai, H., Allen, G.C., Kornberg, A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. A constitutive expression vector system driven by the deo P1P2 promoters of Escherichia coli. Fischer, M., Fytlovitch, S., Amit, B., Wortzel, A., Beck, Y. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
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