Disease relevance of cytR

• Transcriptional regulation of the cytR repressor gene of Escherichia coli: autoregulation and positive control by the cAMP/CAP complex [1].
• Peh production, flagellum synthesis, and virulence reduced in Erwinia carotovora subsp. carotovora by mutation in a homologue of cytR [2].

High impact information on cytR

• The gene maps to 88.7 minutes on the chromosome adjacent to the cytR locus [3].
• Footprinting studies with purified CAP protein revealed two CAP binding sites upstream of the cytR promoter [1].
• A chromosomal cytR-lacZ+ operon fusion was isolated and used to study the regulation of cytR [1].
• DNA sequence analysis of the cytR* mutation revealed a G-C to an A-T base pair transition at position -34 bp relative to the translational initiation site of cytR [1].
• In crude cell extracts hSOD expression levels were found to be high in hosts possessing no deoR or cytR repressors [4].

Analytical, diagnostic and therapeutic context of cytR

• With electron microscopy, the delta cytR mutant was shown to be aflagellate [2].

References