Disease relevance of deoR

• The nucleotide sequence of the deoR gene of E. coli, which codes for the DeoR repressor, has been determined [1].

High impact information on deoR

• Distal effects on the in vivo repression of the deo operon are thought to be mediated by the deoR repressor with DNA loop formation [2].
• Induction of the Ptrc--deoR fusion plasmid resulted in the accumulation of 4% of the soluble protein as deoR protein [3].
• Also, the deoR repressor binds cooperatively in vitro to a DNA template with two deoR binding sites separated by 224 bp in keeping with the conclusion from genetic experiments that more than one operator is required for efficient repression of the deo operon [3].
• From single-copy expression of these fusions it is shown that the deoR binding site of both deoP1 and deoP2 are necessary to achieve full repression of the deo operon by the deoR repressor [4].
• In the present study we report the sequence of a gene encoding a second nucleoside transport system, nupC (in addition to nupG) [5].

Chemical compound and disease context of deoR

• The tse (taxis to serine) gene of E. aerogenes also complements an E. coli tsr mutant; the tas (taxis to aspartate) gene of E. aerogenes complements the defect in aspartate taxis, but not the defect in maltose taxis, of an E. coli tar mutant [6].

Biological context of deoR

• Long-distance deoR regulation of gene expression in Escherichia coli [7].
• Analysis of the regulatory region of the Escherichia coli nupG gene, encoding a nucleoside-transport protein [8].
• The S1-mapping procedure, when applied to an 800-bp fragment upstream of the nupG structural gene of Escherichia coli revealed one transcription-initiation site [8].

Associations of deoR with chemical compounds

• The synthesis is greatly stimulated by deoxyribose-5-phosphate and cyclic AMP indicating that the deoR repressor and the catabolite activating protein (CAP) are highly active under our cell-free conditions [9].

Other interactions of deoR

• In crude cell extracts hSOD expression levels were found to be high in hosts possessing no deoR or cytR repressors [10].
• A new E. coli strain DH11S [mcrA delta(mrr-hsdRMS-mcrBC) delta(lac-proAB) delta(rec1398) deoR rpsL srl- thi-/F'proAB+ lacIqZ delta M 15] has been constructed [11].
• The DNA sequences of the genetic environment surrounding bla(SHV-5) were homologous to plasmid p1658/97 from Escherichia coli, containing a truncated recF gene and a truncated deoR gene upstream and downstream from bla(SHV-5), respectively [12].

References