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Gene Review

deoR  -  deoxyribose-5-phosphate-inducible...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0830, JW0824, nucR
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Disease relevance of deoR


High impact information on deoR

  • Distal effects on the in vivo repression of the deo operon are thought to be mediated by the deoR repressor with DNA loop formation [2].
  • Induction of the Ptrc--deoR fusion plasmid resulted in the accumulation of 4% of the soluble protein as deoR protein [3].
  • Also, the deoR repressor binds cooperatively in vitro to a DNA template with two deoR binding sites separated by 224 bp in keeping with the conclusion from genetic experiments that more than one operator is required for efficient repression of the deo operon [3].
  • From single-copy expression of these fusions it is shown that the deoR binding site of both deoP1 and deoP2 are necessary to achieve full repression of the deo operon by the deoR repressor [4].
  • In the present study we report the sequence of a gene encoding a second nucleoside transport system, nupC (in addition to nupG) [5].

Chemical compound and disease context of deoR


Biological context of deoR


Associations of deoR with chemical compounds

  • The synthesis is greatly stimulated by deoxyribose-5-phosphate and cyclic AMP indicating that the deoR repressor and the catabolite activating protein (CAP) are highly active under our cell-free conditions [9].

Other interactions of deoR

  • In crude cell extracts hSOD expression levels were found to be high in hosts possessing no deoR or cytR repressors [10].
  • A new E. coli strain DH11S [mcrA delta(mrr-hsdRMS-mcrBC) delta(lac-proAB) delta(rec1398) deoR rpsL srl- thi-/F'proAB+ lacIqZ delta M 15] has been constructed [11].
  • The DNA sequences of the genetic environment surrounding bla(SHV-5) were homologous to plasmid p1658/97 from Escherichia coli, containing a truncated recF gene and a truncated deoR gene upstream and downstream from bla(SHV-5), respectively [12].


  1. The primary structure of the DeoR repressor from Escherichia coli K-12. Valentin-Hansen, P., Højrup, P., Short, S. Nucleic Acids Res. (1985) [Pubmed]
  2. Single and double loop formation when deoR repressor binds to its natural operator sites. Amouyal, M., Mortensen, L., Buc, H., Hammer, K. Cell (1989) [Pubmed]
  3. Purification and characterization of the deoR repressor of Escherichia coli. Mortensen, L., Dandanell, G., Hammer, K. EMBO J. (1989) [Pubmed]
  4. Two operator sites separated by 599 base pairs are required for deoR repression of the deo operon of Escherichia coli. Dandanell, G., Hammer, K. EMBO J. (1985) [Pubmed]
  5. Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Craig, J.E., Zhang, Y., Gallagher, M.P. Mol. Microbiol. (1994) [Pubmed]
  6. Evolution of chemotactic-signal transducers in enteric bacteria. Dahl, M.K., Boos, W., Manson, M.D. J. Bacteriol. (1989) [Pubmed]
  7. Long-distance deoR regulation of gene expression in Escherichia coli. Dandanell, G., Norris, K., Hammer, K. Ann. N. Y. Acad. Sci. (1991) [Pubmed]
  8. Analysis of the regulatory region of the Escherichia coli nupG gene, encoding a nucleoside-transport protein. Munch-Petersen, A., Jensen, N. Eur. J. Biochem. (1990) [Pubmed]
  9. Regulated in vitro synthesis of the enzymes of the deo operon of Escerichia coli. properties of the DNA directed system. Svenningsen, B.A. Mol. Gen. Genet. (1975) [Pubmed]
  10. A constitutive expression vector system driven by the deo P1P2 promoters of Escherichia coli. Fischer, M., Fytlovitch, S., Amit, B., Wortzel, A., Beck, Y. Appl. Microbiol. Biotechnol. (1990) [Pubmed]
  11. DH11S: an Escherichia coli strain for preparation of single-stranded DNA from phagemid vectors. Lin, J.J., Smith, M., Jessee, J., Bloom, F. BioTechniques (1992) [Pubmed]
  12. Genetic association of blaSHV-5 with transposable elements IS26 and IS5 in Klebsiella pneumoniae from Taiwan. Yu, W.L., Chen, S.C., Hung, S.W., Chuang, Y.C., Chung, J.G., Chen, I.C., Wu, L.T. Clin. Microbiol. Infect. (2006) [Pubmed]
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