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Gene Review

rplK  -  50S ribosomal subunit protein L11

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3974, JW3946, relC
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Disease relevance of rplK

  • Furthermore, the gene assembly of vbrA-rplk of S. virginiae closely resembled that of nusG-rplK of E. coli, suggesting that vbrA may constitute a part of an essential gene cluster encoding components of transcriptional and translational apparatuses [1].
  • The L11 structural gene, rplK, maping near rif, is carried by the bacteriophage lambdacI857S7drifd18, and is most likely identical with relC [2].

High impact information on rplK

  • The basal level amounts of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in both relA and phenotypically relaxed relA+ rplK (relC) strains were shown to decrease at the onset of amino acid limitation and to remain severely depressed throughout the course of the starvation [3].
  • In addition, rplJp continues to function efficiently in the presence of readthrough transcription from rplKp [4].
  • Subsequent in vitro assays using ribosomes isolated from wild-type and relA and relC mutant strains confirmed that (p)ppGpp is synthesized by ribosomes and that mutation of RelA or L11 blocks that activity [5].
  • Amino acid-deprived rplK (previously known as relC) mutants of Escherichia coli cannot activate (p)ppGpp synthetase I (RelA) and consequently exhibit relaxed phenotypes [6].
  • The secE-nusG genes are cotranscribed, with transcripts initiated at the PEG promoter and terminated at the Rho-independent terminator in the region of the rplK promoter [7].

Biological context of rplK


Other interactions of rplK

  • Second, the four ribosomal protein genes are organized into two separate transcriptional units; rplK and A are in one unit and rplJ and L are in the second unit [10].


  1. Purification and molecular cloning of a butyrolactone autoregulator receptor from Streptomyces virginiae. Okamoto, S., Nihira, T., Kataoka, H., Suzuki, A., Yamada, Y. J. Biol. Chem. (1992) [Pubmed]
  2. A relaxed mutant with an altered ribosomal protein L11. Parker, J., Watson, R.J., Friesen, J.D. Mol. Gen. Genet. (1976) [Pubmed]
  3. Correlation between RNA synthesis and basal level guanosine 5'-diphosphate 3'-diphosphate in relaxed mutants of Escherichia coli. Lagosky, P.A., Chang, F.N. J. Biol. Chem. (1981) [Pubmed]
  4. In vivo analysis of overlapping transcription units in the rplKAJLrpoBC ribosomal protein-RNA polymerase gene cluster of Escherichia coli. Steward, K.L., Linn, T. J. Mol. Biol. (1991) [Pubmed]
  5. Physiological Analysis of the Stringent Response Elicited in an Extreme Thermophilic Bacterium, Thermus thermophilus. Kasai, K., Nishizawa, T., Takahashi, K., Hosaka, T., Aoki, H., Ochi, K. J. Bacteriol. (2006) [Pubmed]
  6. Involvement of the N terminus of ribosomal protein L11 in regulation of the RelA protein of Escherichia coli. Yang, X., Ishiguro, E.E. J. Bacteriol. (2001) [Pubmed]
  7. Sequence and transcriptional pattern of the essential Escherichia coli secE-nusG operon. Downing, W.L., Sullivan, S.L., Gottesman, M.E., Dennis, P.P. J. Bacteriol. (1990) [Pubmed]
  8. Distribution in the genus Streptomyces of a homolog to nusG, a gene encoding a transcriptional antiterminator. Puttikhunt, C., Okamoto, S., Nakamura, T., Nihira, T., Yamada, Y. FEMS Microbiol. Lett. (1993) [Pubmed]
  9. The involvement of 50S ribosomal protein l11 in the EF-G dependent GTP hydrolysis of E. coli ribosomes. Schrier, P.I., Möller, W. FEBS Lett. (1975) [Pubmed]
  10. Organization of genes for transcription and translation in the rif region of the Escherichia coli chromosome. Yamamoto, M., Nomura, M. J. Bacteriol. (1979) [Pubmed]
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