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Gene Review:

dinF - oxidative stress resistance protein;...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4036, JW4004

Norman, A. et al., Piekarowicz, A. et al., Wade, J.T. et al., Sweasy, J.B. et al., Heide, L. et al., et al.

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Disease relevance of dinF

Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes [1].

High impact information on dinF

RNAP preferentially associates with the promoter-proximal region of several operons, and this preference is particularly pronounced at the lexA-dinF promoter [2].
The induction of the DNA-damage inducible SOS response by the Mcr and Mrr systems, in the presence of methylated DNA, is used to select plasmids encoding DNA methyltransferases [3].
The DNA damage-inducible SOS response of Escherichia coli includes an error-prone translesion DNA replication activity responsible for SOS mutagenesis [4].
In the dinF fusion strain, lacZ expression was reduced below that seen in a lexA+ background [5].

Analytical, diagnostic and therapeutic context of dinF

Four different green fluorescent protein (GFP)-based whole-cell biosensors were created based on the DNA damage inducible SOS response of Escherichia coli in order to evaluate the sensitivity of individual SOS promoters toward genotoxic substances [6].

References

Clarification of the Escherichia coli genetic map in the 92-minute region containing the ubiCA operon and the plsB, dgk, lexA, and dinF genes. Heide, L., Melzer, M., Siebert, M., Bechthold, A., Schröder, J., Severin, K. J. Bacteriol. (1993) [Pubmed]
Association of RNA polymerase with transcribed regions in Escherichia coli. Wade, J.T., Struhl, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
A new method for the rapid identification of genes encoding restriction and modification enzymes. Piekarowicz, A., Yuan, R., Stein, D.C. Nucleic Acids Res. (1991) [Pubmed]
RecA protein of Escherichia coli has a third essential role in SOS mutator activity. Sweasy, J.B., Witkin, E.M., Sinha, N., Roegner-Maniscalco, V. J. Bacteriol. (1990) [Pubmed]
Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli. Krueger, J.H., Elledge, S.J., Walker, G.C. J. Bacteriol. (1983) [Pubmed]
Construction of a ColD cda promoter-based SOS-green fluorescent protein whole-cell biosensor with higher sensitivity toward genotoxic compounds than constructs based on recA, umuDC, or sulA promoters. Norman, A., Hestbjerg Hansen, L., Sørensen, S.J. Appl. Environ. Microbiol. (2005) [Pubmed]

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