Gene Review:
lef2 - ORF13
Mamestra configurata nucleopolyhedrovirus B
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Disease relevance of lef2
- The potential role of a late gene expression factor, lef2, from Bombyx mori nuclear polyhedrosis virus in very late gene transcription and DNA replication [1].
High impact information on lef2
- Furthermore, the antisense experiments suggested that lef2 plays a direct role in very late gene transcription [1].
- Transcription start site mapping identified the presence of an aphidicolin-sensitive late transcript arising from a TAAG motif located at -352 nucleotides and an aphidicolin-insensitive early transcript originating from a TTGT motif located 35 nucleotides downstream to a TATA box at -312 nucleotides, with respect to the +1 ATG of lef2 [1].
References
- The potential role of a late gene expression factor, lef2, from Bombyx mori nuclear polyhedrosis virus in very late gene transcription and DNA replication. Sriram, S., Gopinathan, K.P. Virology (1998) [Pubmed]
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