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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

SPAG7  -  sperm associated antigen 7

Homo sapiens

Synonyms: ACRP, FSA-1, MGC20134, Sperm-associated antigen 7
 
 
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High impact information on SPAG7

  • An antibody specific for FSA-1 was used to screen a fox testis cDNA library for its cognate gene [1].
  • A monoclonal antibody was raised to a fox sperm protein (FSA-1) which was found to be localized to the inner acrosomal compartment of sperm fixed in methanol [1].
  • At present, the function of the FSA-1 gene product remains unknown, but it may play a role as a structural protein component of the acrosome [1].
  • Their principal metabolites, following the cleavage of the 14-acyl side-chain, are N-trifluoroacetyladriamycin (AD41) and its reduced form N-trifluoroacetyladriamycinol (AD92) [2].
  • DNA fragmentation was significantly enhanced in the presence of the enzyme and either AD41 or AD92 [2].

References

  1. Cloning and characterization of a fox sperm protein FSA-1. Beaton, S., Cleary, A., ten Have, J., Bradley, M.P. Reprod. Fertil. Dev. (1994) [Pubmed]
  2. Metabolic activation of N-acylanthracyclines precedes their interaction with DNA topoisomerase II. Silber, R., Liu, L.F., Israel, M., Bodley, A.L., Hsiang, Y.H., Kirschenbaum, S., Sweatman, T.W., Seshadri, R., Potmesil, M. NCI monographs : a publication of the National Cancer Institute. (1987) [Pubmed]
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