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Gene Review:

selC - tRNA

Escherichia coli O157:H7 str. EDL933

Schouler, C. et al., Chouikha, I. et al., Sheikh, J. et al., Gr??be, T. et al.

Sheikh, Dudley, Sui, Tamboura, Suleman, Nataro,

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Disease relevance of selC

GrdB could be heterologously produced in Escherichia coli with coexpression of selB and selC from E. acidaminophilum for selenocysteine insertion [1].
The selC locus was also noted to harbour homologues of Salmonella enterica regulator HilA and of invasin from Yersinia spp., yet previous publications suggested that these loci may be silent [2].

High impact information on selC

A selC-associated genomic island of the extraintestinal avian pathogenic Escherichia coli strain BEN2908 is involved in carbohydrate uptake and virulence [3].
This 49,600-bp island is inserted at the selC locus and contains putative mobile genetic elements such as a phage-related integrase gene, transposase genes, and direct repeats [3].
Moreover, several fragments were shown to be located close to tRNA selC, asnT or thrW, which suggests they could be part of pathogenicity islands [4].

References

Peroxidase activity of selenoprotein GrdB of glycine reductase and stabilisation of its integrity by components of proprotein GrdE from Eubacterium acidaminophilum. Gr??be, T., Reuter, M., Gursinsky, T., S??hling, B., Andreesen, J.R. Arch. Microbiol. (2007) [Pubmed]
EilA, a HilA-like regulator in enteroaggregative Escherichia coli. Sheikh, J., Dudley, E.G., Sui, B., Tamboura, B., Suleman, A., Nataro, J.P. Mol. Microbiol. (2006) [Pubmed]
A selC-associated genomic island of the extraintestinal avian pathogenic Escherichia coli strain BEN2908 is involved in carbohydrate uptake and virulence. Chouikha, I., Germon, P., Brée, A., Gilot, P., Moulin-Schouleur, M., Schouler, C. J. Bacteriol. (2006) [Pubmed]
Genomic subtraction for the identification of putative new virulence factors of an avian pathogenic Escherichia coli strain of O2 serogroup. Schouler, C., Koffmann, F., Amory, C., Leroy-Sétrin, S., Moulin-Schouleur, M. Microbiology (Reading, Engl.) (2004) [Pubmed]

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