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Gene Review

CEP135  -  centrosomal protein 135kDa

Homo sapiens

Synonyms: CEP4, Centrosomal protein 4, Centrosomal protein of 135 kDa, Cep135, FLJ13621, ...
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Disease relevance of CEP135

  • Sf9 cells infected with baculovirus containing Cep135 sequences induce filamentous polymers which are distinctive from the whorl seen in CHO cells; #10 forms highly packed spheroids, but the Delta3-containing structure looks loose [1].

High impact information on CEP135

  • However, the oxidant monochloramine rapidly decreased TER and increased mannitol permeability of C2/AS monolayers compared with C2/CEP4 (50% effective doses at 30 minutes were 0.53 +/- 0.11 and 2.06 +/- 0.34 mmol/L, respectively) [2].
  • Because antibodies raised against mammalian centrosome components, such as gamma-tubulin, pericentrin, Cep135, and mitosis-specific phosphoproteins, react strongly with the microtubule-nucleating sites of Lecudina, this protozoan is likely to share common centrosomal antigens with higher eukaryotes [3].
  • Cep135 is a 135-kDa, coiled-coil centrosome protein important for microtubule organization in mammalian cells [Ohta et al., 2002: J. Cell Biol. 156:87-99] [4].
  • To evaluate how the protein is arranged in the centrosomal structure, we overexpressed Cep135 polypeptides in CHO cells by transient transfection [1].

Anatomical context of CEP135

  • It is predicted to be a highly coiled-coil protein with an extensive alpha-helix, suggesting that Cep135 is a structural component of the centrosome [1].


  1. Filamentous polymers induced by overexpression of a novel centrosomal protein, Cep135. Ryu, J.H., Essner, R., Ohta, T., Kuriyama, R. Microsc. Res. Tech. (2000) [Pubmed]
  2. Heat-shock protein 72 protects against oxidant-induced injury of barrier function of human colonic epithelial Caco2/bbe cells. Musch, M.W., Sugi, K., Straus, D., Chang, E.B. Gastroenterology (1999) [Pubmed]
  3. Dynamic organization of microtubules and microtubule-organizing centers during the sexual phase of a parasitic protozoan, Lecudina tuzetae (Gregarine, Apicomplexa). Kuriyama, R., Besse, C., Gèze, M., Omoto, C.K., Schrével, J. Cell Motil. Cytoskeleton (2005) [Pubmed]
  4. Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Uetake, Y., Terada, Y., Matuliene, J., Kuriyama, R. Cell Motil. Cytoskeleton (2004) [Pubmed]
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