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Gene Review

ULK2  -  unc-51 like autophagy activating kinase 2

Homo sapiens

Synonyms: ATG1B, KIAA0623, Serine/threonine-protein kinase ULK2, Unc-51-like kinase 2, Unc51.2
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High impact information on ULK2

  • Mouse ULK2 cDNA encodes a putative polypeptide of 1033 aa which has an overall 52% and 33% amino acid identity to ULK1 and UNC-51, respectively [1].
  • ULK2 gene was mapped to mouse chromosome 11B1.3 and rat chromosome 10q23 by FISH [1].
  • The data presented support a model in which ULK2, by interaction with FRS2/3 and inhibition of SynGAP, functions to negatively regulate tyrosyl phosphorylation of signaling proteins downstream of FGFR1 [2].
  • To characterize the role of UNC-51-like kinase (ULK2) gene in PCD, we investigated cell death effect by ULK2 [3].
  • Theses findings indicated that ULK2 is involved in apoptosis through p53 pathway [3].

Analytical, diagnostic and therapeutic context of ULK2

  • In situ hybridization analysis indicated that ULK2 mRNA is ubiquitously localized in premature as well as mature neurons in developing nervous system [1].
  • Northern blot analysis showed that ULK2 mRNA is widely expressed in adult tissues [1].


  1. Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains. Yan, J., Kuroyanagi, H., Tomemori, T., Okazaki, N., Asato, K., Matsuda, Y., Suzuki, Y., Ohshima, Y., Mitani, S., Masuho, Y., Shirasawa, T., Muramatsu, M. Oncogene (1999) [Pubmed]
  2. UNC-51-like kinase regulation of fibroblast growth factor receptor substrate 2/3. Avery, A.W., Figueroa, C., Vojtek, A.B. Cell. Signal. (2007) [Pubmed]
  3. The Gene Expression Profiling in Murine Cortical Cells Undergoing Programmed Cell Death (PCD) Induced by Serum Deprivation. Yang, M.H., Yoo, K.H., Yook, Y.J., Park, E.Y., Jeon, J.O., Choi, S.H., Park, S.Y., Woo, Y.M., Lee, M.J., Park, J.H. J. Biochem. Mol. Biol. (2007) [Pubmed]
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