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Gene Review

CUL7  -  cullin 7

Homo sapiens

Synonyms: 3M1, CUL-7, Cullin-7, KIAA0076, dJ20C7.5
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High impact information on CUL7

  • Functional studies indicated that the 3-M-associated CUL7 nonsense and missense mutations R1445X and H1464P, respectively, render CUL7 deficient in recruiting ROC1 [1].
  • Studying 29 families with 3-M syndrome (OMIM 273750), an autosomal recessive condition characterized by severe pre- and postnatal growth retardation, we first mapped the underlying gene to chromosome 6p21.1 and then identified 25 distinct mutations in the gene cullin 7 (CUL7) [1].
  • Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development [2].
  • Deletion of the N-terminal domain of CUL7 or a mutation disrupting p53 binding abolished the ability of CUL7 to increase the rate of U2OS cell proliferation [3].
  • CUL7 mediates an essential function for mouse embryo development and has been linked with cell transformation by its physical association with the SV40 large T antigen [3].

Biological context of CUL7

  • Our results suggest that CUL7 functions to promote cell growth through, in part, antagonizing the function of p53 [3].

Other interactions of CUL7

  • Co-expression of CUL7 reduced the transactivating activity of p53 [3].


  1. Identification of mutations in CUL7 in 3-M syndrome. Huber, C., Dias-Santagata, D., Glaser, A., O'Sullivan, J., Brauner, R., Wu, K., Xu, X., Pearce, K., Wang, R., Uzielli, M.L., Dagoneau, N., Chemaitilly, W., Superti-Furga, A., Dos Santos, H., Mégarbané, A., Morin, G., Gillessen-Kaesbach, G., Hennekam, R., Van der Burgt, I., Black, G.C., Clayton, P.E., Read, A., Le Merrer, M., Scambler, P.J., Munnich, A., Pan, Z.Q., Winter, R., Cormier-Daire, V. Nat. Genet. (2005) [Pubmed]
  2. Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T., Nakayama, K.I. Mol. Cell. Biol. (2006) [Pubmed]
  3. Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. Andrews, P., He, Y.J., Xiong, Y. Oncogene (2006) [Pubmed]
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