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Gene Review

NSs  -  non-structural protein

Groundnut bud necrosis virus

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Disease relevance of NSs

  • The 5'-large ORF (1,400 nucleotides in the viral sense (v) strand) encoded a protein with a predicted size of 53.2 kDa that was identified as the nonstructural (NSs) protein based on 16-21% sequence identity and 42-48% sequence similarity with other tospoviruses [1].

High impact information on NSs

  • To gain information on RNA interference (RNAi) in ticks, three known viral inhibitors that act in different ways, the NS1 protein of Influenza virus, NSs of Tospovirus Tomato spotted wilt virus and HC-Pro of Zucchini yellow mosaic virus were expressed and investigated to determine if they antagonize induced RNAi [2].
  • ORFs coding for the non-structural (NSs) and nucleocapsid (N) protein, 439 aa and 275 aa, respectively, were identified on the S RNA (3477 nt) separated by an intergenic region of 1202 nt [3].
  • Using antibodies against a nonstructural protein (NSs) of TSWV, uniform and more diffused staining was observed throughout the cytoplasm of these cells, underlying active genome replication [4].

Biological context of NSs

  • Amino acid sequence comparison of N and NSs proteins revealed identities of 22-34% with the reported tospovirus isolates of serogroups I, II, and III, whereas it had 82-86% identity with viruses in serogroup IV, watermelon silver mottle virus (WSMV) and tomato isolate of peanut bud necrosis (PBNV-To) [5].


  1. Peanut yellow spot virus is a member of a new serogroup of Tospovirus genus based on small (S) RNA sequence and organization. Satyanarayana, T., Gowda, S., Reddy, K.L., Mitchell, S.E., Dawson, W.O., Reddy, D.V. Arch. Virol. (1998) [Pubmed]
  2. Viral suppressors of RNA interference impair RNA silencing induced by a Semliki Forest virus replicon in tick cells. Garcia, S., Billecocq, A., Crance, J.M., Prins, M., Garin, D., Bouloy, M. J. Gen. Virol. (2006) [Pubmed]
  3. The complete nucleotide sequence of a capsicum chlorosis virus isolate from Lycopersicum esculentum in Thailand. Knierim, D., Blawid, R., Maiss, E. Arch. Virol. (2006) [Pubmed]
  4. Multiplication of tomato spotted wilt virus in primary cell cultures derived from two thrips species. Nagata, T., Storms, M.M., Goldbach, R., Peters, D. Virus Res. (1997) [Pubmed]
  5. Peanut bud necrosis tospovirus S RNA: complete nucleotide sequence, genome organization and homology to other tospoviruses. Satyanarayana, T., Mitchell, S.E., Reddy, D.V., Brown, S., Kresovich, S., Jarret, R., Naidu, R.A., Demski, J.W. Arch. Virol. (1996) [Pubmed]
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