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Gene Review

Rep  -  replication initiator protein

Milk vetch dwarf virus

 
 
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Disease relevance of Rep

 

High impact information on Rep

  • The nanovirus Banana bunchy top virus (BBTV) has six standard components in its genome and occasionally contains components encoding additional Rep (replication initiation protein) genes [3].
  • We speculate that RecRep genes have been transferred from viruses or plasmids to parasitic protozoan and bacterial genomes and that Rep proteins were themselves involved in the original recombination events that generated the ancestral RecRep genes [2].

References

  1. The master rep concept in nanovirus replication: identification of missing genome components and potential for natural genetic reassortment. Timchenko, T., Katul, L., Sano, Y., de Kouchkovsky, F., Vetten, H.J., Gronenborn, B. Virology (2000) [Pubmed]
  2. Two families of rep-like genes that probably originated by interspecies recombination are represented in viral, plasmid, bacterial, and parasitic protozoan genomes. Gibbs, M.J., Smeianov, V.V., Steele, J.L., Upcroft, P., Efimov, B.A. Mol. Biol. Evol. (2006) [Pubmed]
  3. Reassortment and concerted evolution in banana bunchy top virus genomes. Hu, J.M., Fu, H.C., Lin, C.H., Su, H.J., Yeh, H.H. J. Virol. (2007) [Pubmed]
 
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