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Gene Review:

HS3ST1 - heparan sulfate (glucosamine) 3-O...

Homo sapiens

Synonyms: 3-OST-1, 3OST, 3OST1, Heparan sulfate 3-O-sulfotransferase 1, Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 1, ...

Liu, J. et al., Liu, J. et al., Liu, J. et al., Myette, J.R. et al., Shworak, N.W. et al., et al.

Shworak, Liu, Petros, Zhang, Kobayashi, Copeland, Jenkins, Rosenberg,

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Disease relevance of HS3ST1

A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread [1].
Expression in Escherichia coli, purification and kinetic characterization of human heparan sulfate 3-O-sulfotransferase-1 [2].

High impact information on HS3ST1

Southern analyses suggest the human 3OST1, 3OST2, and 3OST4 genes, and the corresponding mouse isologs, are single copy [3].
Our previous studies have led us to purify and molecularly clone the heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST-1), which is the key enzyme converting nonanticoagulant heparan sulfate (HSinact) to anticoagulant heparan sulfate (HSact) [4].
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities [4].
3-O-Sulfation of glucosamine by heparan sulfate D-glucosaminyl 3-O-sulfotransferase (3-OST-1) is the key modification in anticoagulant heparan sulfate synthesis [5].

Associations of HS3ST1 with chemical compounds

The purified component was identified as heparan sulfate D-glucosaminyl 3-O-sulfotransferase because it transferred sulfate from [35S]PAPS to the 3-O-position of D-glucosamine and D-glucosamine 6-O-sulfate of HSact precursor and HSinact precursor to produce nearly equivalent amounts of labeled HSact and HSinact [6].

References

A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread. O'Donnell, C.D., Tiwari, V., Oh, M.J., Shukla, D. Virology (2006) [Pubmed]
Expression in Escherichia coli, purification and kinetic characterization of human heparan sulfate 3-O-sulfotransferase-1. Myette, J.R., Shriver, Z., Liu, J., Venkataraman, G., Rosenberg, R., Sasisekharan, R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. Shworak, N.W., Liu, J., Petros, L.M., Zhang, L., Kobayashi, M., Copeland, N.G., Jenkins, N.A., Rosenberg, R.D. J. Biol. Chem. (1999) [Pubmed]
Expression of heparan sulfate D-glucosaminyl 3-O-sulfotransferase isoforms reveals novel substrate specificities. Liu, J., Shworak, N.W., Sinaÿ, P., Schwartz, J.J., Zhang, L., Fritze, L.M., Rosenberg, R.D. J. Biol. Chem. (1999) [Pubmed]
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase-3A sulfates N-unsubstituted glucosamine residues. Liu, J., Shriver, Z., Blaiklock, P., Yoshida, K., Sasisekharan, R., Rosenberg, R.D. J. Biol. Chem. (1999) [Pubmed]
Purification of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Liu, J., Shworak, N.W., Fritze, L.M., Edelberg, J.M., Rosenberg, R.D. J. Biol. Chem. (1996) [Pubmed]

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