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Gene Review

Hs3st1  -  heparan sulfate (glucosamine) 3-O...

Mus musculus

Synonyms: 3-OST, 3-Ost, 3ost, 3ost1, D5Wsu110e, ...
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Disease relevance of Hs3st1

  • Instead, Hs3st1(-/-) mice exhibited genetic background-specific lethality and intrauterine growth retardation, without evidence of a gross coagulopathy [1].
  • In summary, our results indicate that a new member of 3-OST family generates both anticoagulant HS and an entry receptor for herpes simplex virus 1 [2].
  • Our results indicate that a new member of 3-OST family generates an entry receptor for HSV-1 [3].

High impact information on Hs3st1


Biological context of Hs3st1


Associations of Hs3st1 with chemical compounds

  • The 3-O-sulfation of glucosamine by heparan sulfate 3-O-sulfotransferase-1 (3-OST-1) is a key modification step during the biosynthesis of anticoagulant heparan sulfate (HS) [8].

Enzymatic interactions of Hs3st1

  • HS 3-O-sulfotransferases (3-OST) catalyze the transfer of sulfate groups to the 3-O position of glucosamine residues of HS, a rare, but essential HS chain modification required for HS fine structure [9].

Other interactions of Hs3st1


Analytical, diagnostic and therapeutic context of Hs3st1

  • Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase [5].


  1. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. HajMohammadi, S., Enjyoji, K., Princivalle, M., Christi, P., Lech, M., Beeler, D., Rayburn, H., Schwartz, J.J., Barzegar, S., de Agostini, A.I., Post, M.J., Rosenberg, R.D., Shworak, N.W. J. Clin. Invest. (2003) [Pubmed]
  2. Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia, G., Chen, J., Tiwari, V., Ju, W., Li, J.P., Malmstrom, A., Shukla, D., Liu, J. J. Biol. Chem. (2002) [Pubmed]
  3. Characterization of heparan sulphate 3-O-sulphotransferase isoform 6 and its role in assisting the entry of herpes simplex virus type 1. Xu, D., Tiwari, V., Xia, G., Clement, C., Shukla, D., Liu, J. Biochem. J. (2005) [Pubmed]
  4. Crystal structure and mutational analysis of heparan sulfate 3-O-sulfotransferase isoform 1. Edavettal, S.C., Lee, K.A., Negishi, M., Linhardt, R.J., Liu, J., Pedersen, L.C. J. Biol. Chem. (2004) [Pubmed]
  5. Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Shworak, N.W., Liu, J., Fritze, L.M., Schwartz, J.J., Zhang, L., Logeart, D., Rosenberg, R.D. J. Biol. Chem. (1997) [Pubmed]
  6. Mice deficient in heparan sulfate 3-O-sulfotransferase-1: normal hemostasis with unexpected perinatal phenotypes. Shworak, N.W., HajMohammadi, S., de Agostini, A.I., Rosenberg, R.D. Glycoconj. J. (2002) [Pubmed]
  7. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. Chen, J., Duncan, M.B., Carrick, K., Pope, R.M., Liu, J. Glycobiology (2003) [Pubmed]
  8. A conformational change in heparan sulfate 3-O-sulfotransferase-1 is induced by binding to heparan sulfate. Edavettal, S.C., Carrick, K., Shah, R.R., Pedersen, L.C., Tropsha, A., Pope, R.M., Liu, J. Biochemistry (2004) [Pubmed]
  9. Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: I. The 3-O-sulfotransferase family. Cadwallader, A.B., Yost, H.J. Dev. Dyn. (2006) [Pubmed]
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