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MeSH Review:

Erythema Infectiosum

Prikhod'ko, G.G. et al., Kurtzman, G.J. et al., Niebrój-Dobosz, I. et al., Geetha, D. et al., Morinet, F., et al.

Prikhod'ko, Vasilyeva, Reyes, Wong, Brown, Jameson, Busby,

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Disease relevance of Erythema Infectiosum

In two children with acute lymphocytic leukaemia in whom severe anaemia developed, serum samples collected over 9-12 months showed high concentrations of B19 parvovirus, the aertiological agent of fifth disease [1].
The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease) [2].
BACKGROUND: Human parvovirus B19 (B19) is a widely distributed infectious agent, which causes a variety of illnesses including erythema infectiosum (fifth disease) especially in children, arthritis, aplastic crisis, and hydrops fetalis [3].
Human Parvovirus B19 (PV B19) is one of the several recently described 'emerging viruses' and has been identified as the etiological agent of 'fifth disease' in childhood [4].
B19 parvovirus, a non-enveloped DNA virus about 20 nm diameter, is responsible for benign illness in children (fifth disease) or in adult (arthritis) [5].

High impact information on Erythema Infectiosum

Linkages to chromosomes 11q (IDDM4) and 6q (IDDM5) were confirmed by replication, and chromosome 18 may encode a fifth disease locus [6].
In natural infections, B19 antigen and DNA have been detected in sera early in the course of aplastic crisis and only rarely in fifth disease [7].
S-100 protein and GFAP contents in the blood reached significantly high level within the time interval between second and fifth disease weeks, and remained at a relatively high level till patients' death [8].

References

Persistent B19 parvovirus infection as a cause of severe chronic anaemia in children with acute lymphocytic leukaemia. Kurtzman, G.J., Cohen, B., Meyers, P., Amunullah, A., Young, N.S. Lancet (1988) [Pubmed]
The role of parvovirus B19 in aplastic crisis and erythema infectiosum (fifth disease). Chorba, T., Coccia, P., Holman, R.C., Tattersall, P., Anderson, L.J., Sudman, J., Young, N.S., Kurczynski, E., Saarinen, U.M., Moir, R. J. Infect. Dis. (1986) [Pubmed]
Evaluation of a new LightCycler reverse transcription-polymerase chain reaction infectivity assay for detection of human parvovirus B19 in dry-heat inactivation studies. Prikhod'ko, G.G., Vasilyeva, I., Reyes, H., Wong, S., Brown, K.E., Jameson, T., Busby, T.F. Transfusion (2005) [Pubmed]
Pure red cell aplasia caused by Parvovirus B19 infection in solid organ transplant recipients: a case report and review of literature. Geetha, D., Zachary, J.B., Baldado, H.M., Kronz, J.D., Kraus, E.S. Clinical transplantation. (2000) [Pubmed]
B19 parvovirus and blood transfusion. Morinet, F. Dev. Biol. Stand. (1993) [Pubmed]
A genome-wide search for human type 1 diabetes susceptibility genes. Davies, J.L., Kawaguchi, Y., Bennett, S.T., Copeman, J.B., Cordell, H.J., Pritchard, L.E., Reed, P.W., Gough, S.C., Jenkins, S.C., Palmer, S.M. Nature (1994) [Pubmed]
B19 parvovirus replicates in circulating cells of acutely infected patients. Kurtzman, G.J., Gascon, P., Caras, M., Cohen, B., Young, N.S. Blood (1988) [Pubmed]
Immunochemical analysis of some proteins in cerebrospinal fluid and serum of patients with ischemic strokes. Niebrój-Dobosz, I., Rafałowska, J., Lukasiuk, M., Pfeffer, A., Mossakowski, M.J. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (1994) [Pubmed]

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