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MeSH Review

DNA Viruses

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Disease relevance of DNA Viruses


High impact information on DNA Viruses

  • Here we report that both TNF-alpha and TNF-beta have antiviral activity and synergize with interferons (IFNs) in the induction of resistance to both RNA and DNA virus infection in diverse cell types [6].
  • Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA [7].
  • Normal human colon mucosal epithelial cells were cultured in vitro and treated with the oncogenic simian DNA virus (SV40) and the chemical carcinogen azoxymethane [8].
  • Enhancement of the replication of unrelated viruses (three RNA viruses and one DNA virus), representative of four major virus groups, occurs in human, rodent, or avian cells treated in vitro with 5-iododeoxyuridine (IdU) [9].
  • Recent studies with DNA viruses have contributed to our understanding of critical tumor targets (such as EGFR, PP2A, Rb and p53) and have an impact on the development of novel therapies, including oncolytic viral agents, for the treatment of cancer [10].

Chemical compound and disease context of DNA Viruses


Biological context of DNA Viruses


Anatomical context of DNA Viruses

  • We have previously reported the cloning and structural analysis of integrated hepatitis B virus DNA copies from the human hepatoma cell line PLC/PRF/5 [21].
  • Cloned BamHI D1 fragment (approximately equal to 9 kbp) from AG-876 virus DNA, or a combination of cloned BamHI X and H fragments (approximately equal to 2 and 7 kbp, respectively) from the similar region of B95-8 virus DNA, significantly stimulated lymphocyte DNA synthesis, but EBNA could not be detected and transformation was not achieved [22].
  • Unexpected parallels between several of nature's most efficient DNA viruses and nonviral polyethylenimine/DNA nanocomplexes were revealed to include motor protein-driven transport through the cytoplasm toward the nucleus on microtubules [23].
  • Chemokine homologs are encoded by many large DNA viruses, suggesting that they contribute to control of host leukocyte transmigration and trafficking during viral infection [24].
  • Unlike other DNA virus vectors, AAV is a stably integrating virus, which could make possible long-term in vivo complementation of the CF defect in the airway epithelium [25].

Gene context of DNA Viruses


Analytical, diagnostic and therapeutic context of DNA Viruses


  1. Hepatitis B virus contains protein attached to the 5' terminus of its complete DNA strand. Gerlich, W.H., Robinson, W.S. Cell (1980) [Pubmed]
  2. Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA. Mocarski, E.S., Roizman, B. Cell (1982) [Pubmed]
  3. Selective transcription of vaccinia virus genes in template dependent soluble extracts of infected cells. Puckett, C., Moss, B. Cell (1983) [Pubmed]
  4. Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. Studies in percutaneous liver biopsies and post-mortem tissue specimens. Shafritz, D.A., Shouval, D., Sherman, H.I., Hadziyannis, S.J., Kew, M.C. N. Engl. J. Med. (1981) [Pubmed]
  5. Acquisition of the human adeno-associated virus type-2 rep gene by human herpesvirus type-6. Thomson, B.J., Efstathiou, S., Honess, R.W. Nature (1991) [Pubmed]
  6. Tumour necrosis factors alpha and beta inhibit virus replication and synergize with interferons. Wong, G.H., Goeddel, D.V. Nature (1986) [Pubmed]
  7. Steroid-free glucocorticoid receptor binds specifically to mouse mammary tumour virus DNA. Willmann, T., Beato, M. Nature (1986) [Pubmed]
  8. Human colon cells: culture and in vitro transformation. Moyer, M.P., Aust, J.B. Science (1984) [Pubmed]
  9. 5-iododeoxyuridine potentiation of the replication in vitro of several unrelated RNA and DNA viruses. Green, J.A., Baron, S. Science (1975) [Pubmed]
  10. DNA tumor viruses -- the spies who lyse us. O'Shea, C.C. Curr. Opin. Genet. Dev. (2005) [Pubmed]
  11. Quantitative assessment of hepatitis B virus DNA during a 24-week course of lamivudine therapy. Honkoop, P., de Man, R.A., Niesters, H.G. Ann. Intern. Med. (1998) [Pubmed]
  12. Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections. De Clercq, E. Clin. Microbiol. Rev. (2003) [Pubmed]
  13. Elimination of naturally occurring crosslinks in vaccinia virus DNA after viral penetration into cells. Pogo, B.G. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  14. Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I. Shuman, S., Kane, E.M., Morham, S.G. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  15. Murine cytomegalovirus infects spermatogenic cells. Dutko, F.J., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  16. The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma. Nagaya, T., Nakamura, T., Tokino, T., Tsurimoto, T., Imai, M., Mayumi, T., Kamino, K., Yamamura, K., Matsubara, K. Genes Dev. (1987) [Pubmed]
  17. Polyprotein processing in African swine fever virus: a novel gene expression strategy for a DNA virus. Simón-Mateo, C., Andrés, G., Viñuela, E. EMBO J. (1993) [Pubmed]
  18. A geminivirus replication protein interacts with the retinoblastoma protein through a novel domain to determine symptoms and tissue specificity of infection in plants. Kong, L.J., Orozco, B.M., Roe, J.L., Nagar, S., Ou, S., Feiler, H.S., Durfee, T., Miller, A.B., Gruissem, W., Robertson, D., Hanley-Bowdoin, L. EMBO J. (2000) [Pubmed]
  19. OCSBF-1, a maize ocs enhancer binding factor: isolation and expression during development. Singh, K., Dennis, E.S., Ellis, J.G., Llewellyn, D.J., Tokuhisa, J.G., Wahleithner, J.A., Peacock, W.J. Plant Cell (1990) [Pubmed]
  20. Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Wang, X.W., Forrester, K., Yeh, H., Feitelson, M.A., Gu, J.R., Harris, C.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  21. Co-transcribed 3' host sequences augment expression of integrated hepatitis B virus DNA. von Loringhoven, A.F., Koch, S., Hofschneider, P.H., Koshy, R. EMBO J. (1985) [Pubmed]
  22. Expression of Epstein-Barr virus (EBV) DNA and cloned DNA fragments in human lymphocytes following Sendai virus envelope-mediated gene transfer. Volsky, D.J., Gross, T., Sinangil, F., Kuszynski, C., Bartzatt, R., Dambaugh, T., Kieff, E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  23. Efficient active transport of gene nanocarriers to the cell nucleus. Suh, J., Wirtz, D., Hanes, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  24. Cytomegalovirus-encoded beta chemokine promotes monocyte-associated viremia in the host. Saederup, N., Lin, Y.C., Dairaghi, D.J., Schall, T.J., Mocarski, E.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  25. Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector. Flotte, T.R., Afione, S.A., Conrad, C., McGrath, S.A., Solow, R., Oka, H., Zeitlin, P.L., Guggino, W.B., Carter, B.J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  26. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. Kraus, T.A., Lau, J.F., Parisien, J.P., Horvath, C.M. J. Biol. Chem. (2003) [Pubmed]
  27. Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line. Armengol, C., Tarafa, G., Boix, L., Solé, M., Queralt, R., Costa, D., Bachs, O., Bruix, J., Capellá, G. Clin. Cancer Res. (2004) [Pubmed]
  28. A single rep protein initiates replication of multiple genome components of faba bean necrotic yellows virus, a single-stranded DNA virus of plants. Timchenko, T., de Kouchkovsky, F., Katul, L., David, C., Vetten, H.J., Gronenborn, B. J. Virol. (1999) [Pubmed]
  29. Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Sainz, B., Mossel, E.C., Peters, C.J., Garry, R.F. Virology (2004) [Pubmed]
  30. Induction of intercellular adhesion molecule-1 (CD54) on human hepatoma cell line HepG2: influence of cytokines and hepatitis B virus-DNA transfection. Volpes, R., van den Oord, J.J., Desmet, V.J., Yap, S.H. Clin. Exp. Immunol. (1992) [Pubmed]
  31. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hsu, H.C., Chiou, T.J., Chen, J.Y., Lee, C.S., Lee, P.H., Peng, S.Y. Hepatology (1991) [Pubmed]
  32. Changes of hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: analysis of intrahepatic replicative hepatitis B virus DNA. Yokosuka, O., Omata, M., Imazeki, F., Okuda, K., Summers, J. Hepatology (1985) [Pubmed]
  33. A case-control study on a novel DNA virus (TT virus) infection and hepatocellular carcinoma. The Brescia HCC Study. Tagger, A., Donato, F., Ribero, M.L., Binelli, G., Gelatti, U., Portera, G., Albertini, A., Fasola, M., Chiesa, R., Nardi, G. Hepatology (1999) [Pubmed]
  34. Cellular engineering and gene therapy strategies for insulin replacement in diabetes. Newgard, C.B. Diabetes (1994) [Pubmed]
  35. Specific inhibition of DNA polymerase-associated RNase H by DNA. Modak, M.J., Marcus, S.L. J. Virol. (1977) [Pubmed]
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