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MeSH Review

Genes, RAG-1

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High impact information on Genes, RAG-1

  • CD19+CD10+ human B lineage bone marrow cells were separated into cycling or resting cells, which differ in their expression of CD34, VpreB, recombination activating gene (RAG-1), and terminal deoxynucleotidyl transferase (TdT) [1].
  • After 13-15 days, transcripts for the recombinase activating genes (RAG) 1 and 2, interleukin (IL) 7, IL-7 receptor and c-kit were expressed [2].
  • Thus far, inherited hypomorphic mutations of the recombination activating genes 1 and 2 (RAG1/2) have been described in OS [3].
  • Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery [4].
  • During V(D)J recombination, recognition and cleavage of the recombination signal sequences (RSSs) requires the coordinated action of the recombination-activating genes 1 and 2 (RAG1/RAG2) recombinase complex [5].

Biological context of Genes, RAG-1


Anatomical context of Genes, RAG-1


Gene context of Genes, RAG-1


  1. Ordering of human bone marrow B lymphocyte precursors by single-cell polymerase chain reaction analyses of the rearrangement status of the immunoglobulin H and L chain gene loci. Ghia, P., ten Boekel, E., Sanz, E., de la Hera, A., Rolink, A., Melchers, F. J. Exp. Med. (1996) [Pubmed]
  2. In vitro generation of lymphoid precursors from embryonic stem cells. Potocnik, A.J., Nielsen, P.J., Eichmann, K. EMBO J. (1994) [Pubmed]
  3. Omenn syndrome due to ARTEMIS mutations. Ege, M., Ma, Y., Manfras, B., Kalwak, K., Lu, H., Lieber, M.R., Schwarz, K., Pannicke, U. Blood (2005) [Pubmed]
  4. Cutting edge: CD40-induced expression of recombination activating gene (RAG) 1 and RAG2: a mechanism for the generation of autoaggressive T cells in the periphery. Vaitaitis, G.M., Poulin, M., Sanderson, R.J., Haskins, K., Wagner, D.H. J. Immunol. (2003) [Pubmed]
  5. Definition of minimal domains of interaction within the recombination-activating genes 1 and 2 recombinase complex. Aidinis, V., Dias, D.C., Gomez, C.A., Bhattacharyya, D., Spanopoulou, E., Santagata, S. J. Immunol. (2000) [Pubmed]
  6. Expression of the recombinase-activating gene (RAG-1) in murine early embryogenesis. Hayakawa, S., Tochigi, M., Chishima, F., Shiraishi, H., Takahashi, N., Watanabe, K., Fujii, K.T., Satoh, K. Immunol. Cell Biol. (1996) [Pubmed]
  7. Development of T cell receptor-gamma delta cells. Phenotypic and functional correlations of T cell receptor-gamma delta thymocyte maturation. Tatsumi, Y., Pena, J.C., Matis, L., Deluca, D., Bluestone, J.A. J. Immunol. (1993) [Pubmed]
  8. CD3-CD8+ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL. Lin, T., Matsuzaki, G., Yoshida, H., Kobayashi, N., Kenai, H., Omoto, K., Nomoto, K. Eur. J. Immunol. (1994) [Pubmed]
  9. The taming of a transposon: V(D)J recombination and the immune system. Jones, J.M., Gellert, M. Immunol. Rev. (2004) [Pubmed]
  10. bcl-xL and RAG genes are induced and the response to IL-2 enhanced in EmuEBNA-1 transgenic mouse lymphocytes. Tsimbouri, P., Drotar, M.E., Coy, J.L., Wilson, J.B. Oncogene (2002) [Pubmed]
  11. Mutations in the RNA component of RNase mitochondrial RNA processing might cause Omenn syndrome. Roifman, C.M., Gu, Y., Cohen, A. J. Allergy Clin. Immunol. (2006) [Pubmed]
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