Disease relevance of Spherocytes

• An immune-mediated basis for the hemolytic anemia was suggested by its abrogation in cyclophosphamide-treated mice, as well as an abnormal number of spherocytes in the circulation [1].

High impact information on Spherocytes

• However, propranolol hydrochloride, a cationic anesthetic that does not prevent ATP depletion, inhibited fragmentation and the appearance of myelin forms in both hereditary spherocytes and xerocytes [2].
• Transfusion medicine illustrated. A surfeit of spherocytes [3].
• The quantitation of spherocytes in ABO hemolytic disease [4].
• We aimed to clarify the role of EPO in the response to enhanced spherocyte destruction, and to look for a linkage with the broad clinical spectra of HS [5].
• Therefore in spectrin deficient erythrocytes the induction of cytoskeletal damage, specifically recognized by PCMT type II, could be one of the splenic steps producing conditioned spherocytes [6].

Biological context of Spherocytes

• Normal red blood cells that were induced to become spherocytes by different means (i.e., vinblastine, lysophosphatidyl choline, and heat) and showed increased osmotic fragility did not become susceptible to the hypertonic cryohemolysis conditions [7].
• Methylmercuric chloride produced an irregularity of cell shape with spicules including the final stage of spherocytes. p-Chloromercuribenzoic acid formed crenated cells with protrusion, then spherocytes [8].
• Erythrocytes of Hb SF heterozygote were changed to spherocytes and began to lyse after incubation with sodium salicylate or sulfadiazine (pH 7.4, 37 degrees C) for 2 - 4 h [9].

Associations of Spherocytes with chemical compounds

• Red cells were quite rapidly transformed from a discoid configuration to crumbled discs, echinocytes and spherocytes, but no debris or burst cell configurations were seen [10].
• Moreover, at higher concentration of progesterone, stomatocytes emerged prominently (1.0 X 10(-4) M progesterone), followed by the increase in spherocytes (2.0 X 10(-4) M) [11].
• Primaquine converts erythrocytes into osmotically fragile spherocytes [12].
• In the scanning study, the normal biconcave shape of the erythrocytes was changed to rugged surface spherocytes when mercuric chloride was added to the erythrocyte suspension [8].
• Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes [13].

Gene context of Spherocytes

• The activation required both extracellular Ca2+ and A23187, and was accompanied by the degradation of some membrane proteins and morphological changes in erythrocyte shape from discocytes to echinodisks, echinocytes, and spherocytes [14].
• Fresh hereditary spherocytes were very resistant to lysis by phospholipase C, but, like normal erythrocytes, became progressively more susceptible to lysis upon storage [15].

References