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MeSH Review

Osmotic Fragility

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Disease relevance of Osmotic Fragility


High impact information on Osmotic Fragility


Chemical compound and disease context of Osmotic Fragility


Biological context of Osmotic Fragility


Anatomical context of Osmotic Fragility


Associations of Osmotic Fragility with chemical compounds


Gene context of Osmotic Fragility

  • Finally, we show that increased HDL cholesterol levels due to SR-BI deficiency induce erythrocyte cholesterol:phospholipid ratios, resulting in decreased deformability and increased osmotic fragility, thereby providing an explanation for the observed reduced lifespan [29].
  • The genetic basis for the osmotic fragility and elevated pyr enzyme synthesis was the result of mutations affecting pyrH, encoding the enzyme uridine 5'-monophosphate kinase [30].
  • The genetic basis for erythrocyte osmotic fragility differences between mouse strains C57BL/6 and DBA/2 was examined through analyses of their serial backcross progeny, recombinant inbred (ri) strains (BXD), and congenic C57BL/6 strains with allelic differences at Hbb or Fv-2 [31].
  • The addition of exogenous glutathione (50 mg 100 ml-1) or glutathione reductase and NADPH to rat blood in the presence of Alcide returned erythrocyte osmotic fragility to control values [32].
  • Red cells incubated with plasma had decreased membrane cholesterol and increased osmotic fragility, but the change was prevented by the inactivation of lecithin cholesterol acyltransferase (LCAT) in the plasma [33].

Analytical, diagnostic and therapeutic context of Osmotic Fragility


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