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MeSH Review:

Melkersson-Rosenthal Syndrome

Kruse-Lösler, B. et al., Ruza Paz-Curbera, E. et al., Fdez-Freire, L.R. et al., Tsuboi, H. et al., Coskun, B. et al., et al.

Kruse-Lösler, Presser, Metze, Joos,

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Disease relevance of Melkersson-Rosenthal Syndrome

Tranilast has been described as an effective treatment for cases of MRS, granulomatous cheilitis, and granulomatous blepharitis [1].
A variant of granulomatous cheilitis is Melkersson-Rosenthal syndrome when associated with facial paralysis and furrowed tongue [2].

High impact information on Melkersson-Rosenthal Syndrome

CONCLUSIONS: Reduction cheiloplasty is an effective method to correct persistent macrocheilia and improve lip aesthetics in patients with Melkersson-Rosenthal syndrome or granulomatous cheilitis in the persistent state of disease [3].
Successful treatment of granulomatous cheilitis with thalidomide [4].
Clofazimine as elective treatment for granulomatous cheilitis [2].
Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole [5].
This is the classic triad which defines the syndrome, although it is accepted that the presence of two manifestations or one with a granulomatous cheilitis in the biopsy, are sufficient to make the diagnosis [6].

Chemical compound and disease context of Melkersson-Rosenthal Syndrome

Minocycline in granulomatous cheilitis: experience with 6 cases [7].

References

A case of vulvitis granulomatosa. Tsuboi, H., Masuzawa, M., Katsuoka, K. J. Dermatol. (2005) [Pubmed]
Clofazimine as elective treatment for granulomatous cheilitis. Fdez-Freire, L.R., Serrano Gotarredona, A., Bernabeu Wittel, J., Pulpillo Ruiz, A., Cabrera, R., Navarrete Ortega, M., Conejo-Mir, J. Journal of drugs in dermatology : JDD. (2005) [Pubmed]
Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa. Kruse-Lösler, B., Presser, D., Metze, D., Joos, U. Archives of dermatology. (2005) [Pubmed]
Successful treatment of granulomatous cheilitis with thalidomide. Thomas, P., Walchner, M., Ghoreschi, K., Röcken, M. Archives of dermatology. (2003) [Pubmed]
Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole. Coskun, B., Saral, Y., Cicek, D., Akpolat, N. The Journal of dermatological treatment. (2004) [Pubmed]
Melkersson-Rosenthal syndrome in a diabetic boy. Ruza Paz-Curbera, E., Fernández Benítez, M. Allergologia et immunopathologia. (1998) [Pubmed]
Minocycline in granulomatous cheilitis: experience with 6 cases. Veller Fornasa, C., Catalano, P., Peserico, A. Dermatology (Basel) (1992) [Pubmed]

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