Disease relevance of Suipoxvirus

• The fourth ORF, MF8a, shows similarity to the ORFs found in the same position relative to the TK genes of Shope fibroma virus, Kenya sheep-1 virus and swine-pox virus [1].
• In addition, several polypeptides encoded within the near-terminal regions of vaccinia virus DNA that function as host range or virulence factors are lacking within this region of swinepox virus including the VV growth factor, complement-binding protein, and ORFs C7L and K1L, associated with host range [2].

High impact information on Suipoxvirus

• Pseudosubstrate inhibition of protein kinase PKR by swine pox virus C8L gene product [3].
• Feline B7.1 and B7.2 proteins produced from swinepox virus vectors are natively processed and biologically active: potential for use as nonchemical adjuvants [4].
• Effects of cyclophosphamide on pigs infected and vaccinated with swinepox virus [5].

Gene context of Suipoxvirus

• Isolation and molecular characterization of the swinepox virus thymidine kinase gene [6].

Analytical, diagnostic and therapeutic context of Suipoxvirus

• Piglets treated with cyclophosphamide (50 mg/kg body wt, iv) before infection/vaccination with swinepox virus showed a strong suppression of humoral immune response [5].

References