Disease relevance of Tumor Virus Infections

• Heparin also blocks infections by cowpox virus, rabbitpox virus, myxoma virus, and Shope fibroma virus, suggesting that cell surface heparan sulfate could be a general mediator of the entry of poxviruses [1].
• Infection of cultured mammalian cells with the Leporipoxvirus Shope fibroma virus (SFV) causes the induction of a novel uracil DNA glycosylase activity in the cytoplasms of the infected cells [2].
• Phosphonoacetic acid treatment of shope fibroma and vaccinia virus skin infections in rabbits [3].
• Myxoma virus and Shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability [4].
• We show that a homologue to this third ORF is absent from VV and FPV DNAs, but is present downstream of the TK gene on Shope fibroma virus DNA [5].

High impact information on Tumor Virus Infections

• An open reading frame, BamHI D6R, from the central highly conserved region of the Shope fibroma virus (SFV) genome was sequenced and found to have significant homology to that of uracil DNA glycosylases from a number of organisms [6].
• The thymidine kinase (TK) gene of Shope fibroma virus (SFV), a tumorigenic leporipoxvirus, was localized within the viral genome with degenerate oligonucleotide probes [7].
• Shope fibroma virus. II. Role of the virion-associated nucleases [8].
• Calcium phosphate precipitates were used to cotransfect Shope fibroma virus-infected cells with different DNA substrates and the recombinant products assayed by genetic and biochemical methods [9].
• Here, we demonstrate that expression of soluble interferon-gamma receptor homologs appears to be characteristic of all poxviruses tested, including Shope fibroma virus, vaccinia virus (strains WR and IHDW), ectromelia virus, cowpox virus, and rabbitpox virus [10].

Chemical compound and disease context of Tumor Virus Infections

• Activation by 5-iododeoxyuridine of shope papilloma viral genome in cultured VX2 and VX7 carcinomas [11].

Biological context of Tumor Virus Infections

• A synthetic 55-residue peptide consisting of the carboxyl portion of the predicted genomic DNA sequence of Shope fibroma virus growth factor (SFGF residue 26-80) was found to exhibit epidermal growth factor-transforming growth factor activities in newborn mice [12].

Gene context of Tumor Virus Infections

• T2 open reading frame from the Shope fibroma virus encodes a soluble form of the TNF receptor [13].
• Transforming growth factor alpha, Shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits [14].
• Shope fibroma virus growth factor exhibits epidermal growth factor activities in newborn mice [12].
• The highly recombinant environment resulting from infection of rabbit cornea cells with the Shope fibroma virus was exploited to mediate precise modifications of the complete chicken lysozyme gene domain (21.5 kb) [15].

References