The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Cd86  -  CD86 antigen

Mus musculus

Synonyms: Activation B7-2 antigen, B7, B7-2, B7.2, B70, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cd86


High impact information on Cd86

  • Here we show that these pathways are differentially activated by two costimulatory molecules, B7-1 and B7-2 [5].
  • B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells [6].
  • Our findings demonstrate that B7.2 induces expansion of CD8+ T cells and B7.1 governs their acquisition of cytolytic activity [7].
  • Although the vesicles exclude soluble lysosomal contents and antigen-processing machinery, many contain MHC I and B7 costimulatory molecules [8].
  • Full reconstitution of cellular and humoral immunity was achieved in CD40L-deficient mice by administration of an activating antibody to CD40 that increased expression of B7.2 on spleen cells [9].

Chemical compound and disease context of Cd86


Biological context of Cd86


Anatomical context of Cd86

  • Our data suggests that B7-2 expressed on some T cell tumors inhibits development of antitumor immunity, and IL-4 appears to play a critical role in abrogation of the antitumor immune response [2].
  • These results reveal a critical role for costimulatory molecules B7-1 and B7-2 in deleting pathogenic autoreactive T cells in the thymus [1].
  • Mice lacking both B7-1 and B7-2 or CD28 showed no or minimal clinical signs of EAE and markedly reduced inflammatory infiltrates in the brain and spinal cord [16].
  • B7-1 and B7-2 are costimulatory molecules expressed on antigen-presenting cells [17].
  • Antibody-depletion studies in vivo showed that CD8+ T cells rejected C1498/B7-2, whereas only natural killer cells affected the growth of C1498/B7-1 [4].

Associations of Cd86 with chemical compounds


Physical interactions of Cd86


Regulatory relationships of Cd86


Other interactions of Cd86

  • In sharp contrast, spontaneous diabetes is exacerbated in both B7-1/B7-2-deficient and CD28-deficient NOD mice [29].
  • Similar effects of anti-B7-2 on CD4 cell cytokine expression were observed in IL-4 knockout mice, indicating the existence of an alternative pathway for induction and/or expression of these cytokine genes [30].
  • We have also detected a higher ratio of CD4+/CD8+ T cells and increased expression of B7.1/B7.2 on B cells and antigen-presenting cells in IFNB knockout mice [31].
  • Flow cytometric analysis of dispersed lung cells showed that expression of IL-10 in the airway reduced the absolute number of Class II major histocompatibility complex (MHC)(+)/CD11c(+) (dendritic cells) and Class II MHC(+)/Mac-1(bright) (macrophages) cells expressing the costimulatory molecules B7.1 and B7.2 by 30% [32].
  • Finally, blockade of CD40/CD40L interaction was inferior to blockade of B7-2/CD28 interaction in inhibiting the generation of CTL activity by tumor bearer splenic cells stimulated in the presence of exogenous TNF [26].

Analytical, diagnostic and therapeutic context of Cd86


  1. Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. Gao, J.X., Zhang, H., Bai, X.F., Wen, J., Zheng, X., Liu, J., Zheng, P., Liu, Y. J. Exp. Med. (2002) [Pubmed]
  2. B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. Stremmel, C., Greenfield, E.A., Howard, E., Freeman, G.J., Kuchroo, V.K. J. Exp. Med. (1999) [Pubmed]
  3. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. Racke, M.K., Scott, D.E., Quigley, L., Gray, G.S., Abe, R., June, C.H., Perrin, P.J. J. Clin. Invest. (1995) [Pubmed]
  4. Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. Blood (2002) [Pubmed]
  5. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N., Glimcher, L.H. Cell (1995) [Pubmed]
  6. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Dong, H., Strome, S.E., Salomao, D.R., Tamura, H., Hirano, F., Flies, D.B., Roche, P.C., Lu, J., Zhu, G., Tamada, K., Lennon, V.A., Celis, E., Chen, L. Nat. Med. (2002) [Pubmed]
  7. Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. King, C., Mueller Hoenger, R., Malo Cleary, M., Murali-Krishna, K., Ahmed, R., King, E., Sarvetnick, N. Nat. Med. (2001) [Pubmed]
  8. Transport of peptide-MHC class II complexes in developing dendritic cells. Turley, S.J., Inaba, K., Garrett, W.S., Ebersold, M., Unternaehrer, J., Steinman, R.M., Mellman, I. Science (2000) [Pubmed]
  9. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Yang, Y., Wilson, J.M. Science (1996) [Pubmed]
  10. Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Reiser, H., Schneeberger, E.E. Eur. J. Immunol. (1996) [Pubmed]
  11. Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. Sojka, D.K., Donepudi, M., Bluestone, J.A., Mokyr, M.B. J. Immunol. (2000) [Pubmed]
  12. 4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae. Wu, Z.Q., Khan, A.Q., Shen, Y., Wolcott, K.M., Dawicki, W., Watts, T.H., Mittler, R.S., Snapper, C.M. Infect. Immun. (2003) [Pubmed]
  13. The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Reeves, R.H., Patch, D., Sharpe, A.H., Borriello, F., Freeman, G.J., Edelhoff, S., Disteche, C. Mamm. Genome (1997) [Pubmed]
  14. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Borriello, F., Sethna, M.P., Boyd, S.D., Schweitzer, A.N., Tivol, E.A., Jacoby, D., Strom, T.B., Simpson, E.M., Freeman, G.J., Sharpe, A.H. Immunity (1997) [Pubmed]
  15. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. Lenschow, D.J., Sperling, A.I., Cooke, M.P., Freeman, G., Rhee, L., Decker, D.C., Gray, G., Nadler, L.M., Goodnow, C.C., Bluestone, J.A. J. Immunol. (1994) [Pubmed]
  16. Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. Chang, T.T., Jabs, C., Sobel, R.A., Kuchroo, V.K., Sharpe, A.H. J. Exp. Med. (1999) [Pubmed]
  17. Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody. Vanhove, B., Laflamme, G., Coulon, F., Mougin, M., Vusio, P., Haspot, F., Tiollier, J., Soulillou, J.P. Blood (2003) [Pubmed]
  18. Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Stephens, L.A., Kay, T.W. Int. Immunol. (1995) [Pubmed]
  19. Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages. Hunter, K.W., DuPre', S., Redelman, D. Immunol. Lett. (2004) [Pubmed]
  20. Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene. Ramesh, R., Munshi, A., Abboud, C.N., Marrogi, A.J., Freeman, S.M. Cancer Gene Ther. (1996) [Pubmed]
  21. Induction of costimulatory molecules B7-1 and B7-2 in murine B cells. the CBA/N mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction. Goldstein, M.D., Debenedette, M.A., Hollenbaugh, D., Watts, T.H. Mol. Immunol. (1996) [Pubmed]
  22. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K.S., Sakuta, H., Azuma, M., Yagita, H., Okumura, K., Linsley, P.S., Ikehara, S., Muramatsu, S., Hodes, R.J., Steinman, R.M. J. Exp. Med. (1994) [Pubmed]
  23. Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain. Guo, Y., Wu, Y., Zhao, M., Kong, X.P., Liu, Y. J. Exp. Med. (1995) [Pubmed]
  24. CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice. Maletto, B., Rópolo, A., Morón, V., Pistoresi-Palencia, M.C. J. Leukoc. Biol. (2002) [Pubmed]
  25. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Roy, M., Aruffo, A., Ledbetter, J., Linsley, P., Kehry, M., Noelle, R. Eur. J. Immunol. (1995) [Pubmed]
  26. Limited importance of CD40/CD40L interaction in the B7-dependent generation of anti-MOPC-315 cytotoxic T lymphocyte activity by tumor bearer splenic cells stimulated in vitro in the presence of tumor necrosis factor. Kalinichenko, T.V., Mokyr, M.B. Cancer Immunol. Immunother. (1998) [Pubmed]
  27. B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Buono, C., Pang, H., Uchida, Y., Libby, P., Sharpe, A.H., Lichtman, A.H. Circulation (2004) [Pubmed]
  28. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. Greenfield, E.A., Howard, E., Paradis, T., Nguyen, K., Benazzo, F., McLean, P., Höllsberg, P., Davis, G., Hafler, D.A., Sharpe, A.H., Freeman, G.J., Kuchroo, V.K. J. Immunol. (1997) [Pubmed]
  29. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Salomon, B., Lenschow, D.J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., Bluestone, J.A. Immunity (2000) [Pubmed]
  30. B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. Subramanian, G., Kazura, J.W., Pearlman, E., Jia, X., Malhotra, I., King, C.L. J. Immunol. (1997) [Pubmed]
  31. Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene. Matheu, V., Treschow, A., Navikas, V., Issazadeh-Navikas, S. J. Allergy Clin. Immunol. (2003) [Pubmed]
  32. Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Stämpfli, M.R., Cwiartka, M., Gajewska, B.U., Alvarez, D., Ritz, S.A., Inman, M.D., Xing, Z., Jordana, M. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  33. Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. Chen, C., Gault, A., Shen, L., Nabavi, N. J. Immunol. (1994) [Pubmed]
  34. Differential expression of costimulatory molecules B7-1 and B7-2 on microglial cells induced by Th1 and Th2 cells in organotypic brain tissue. Wolf, S.A., Gimsa, U., Bechmann, I., Nitsch, R. Glia (2001) [Pubmed]
  35. T cells are the main cell type expressing B7-1 and B7-2 in the central nervous system during acute, relapsing and chronic experimental autoimmune encephalomyelitis. Cross, A.H., Lyons, J.A., San, M., Keeling, R.M., Ku, G., Racke, M.K. Eur. J. Immunol. (1999) [Pubmed]
  36. B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Akiyama, Y., Shirasugi, N., Uchida, N., Matsumoto, K., Kitajima, M., Bashuda, H., Yagita, H., Okumura, K., Aramaki, O., Niimi, M. Transplantation (2002) [Pubmed]
WikiGenes - Universities