Gene Review:
Cd86 - CD86 antigen
Mus musculus
Synonyms:
Activation B7-2 antigen, B7, B7-2, B7.2, B70, ...
- Perinatal blockade of b7-1 and b7-2 inhibits clonal deletion of highly pathogenic autoreactive T cells. Gao, J.X., Zhang, H., Bai, X.F., Wen, J., Zheng, X., Liu, J., Zheng, P., Liu, Y. J. Exp. Med. (2002)
- B7-2 expressed on EL4 lymphoma suppresses antitumor immunity by an interleukin 4-dependent mechanism. Stremmel, C., Greenfield, E.A., Howard, E., Freeman, G.J., Kuchroo, V.K. J. Exp. Med. (1999)
- Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. Racke, M.K., Scott, D.E., Quigley, L., Gray, G.S., Abe, R., June, C.H., Perrin, P.J. J. Clin. Invest. (1995)
- Negative effect of CTLA-4 on induction of T-cell immunity in vivo to B7-1+, but not B7-2+, murine myelogenous leukemia. LaBelle, J.L., Hanke, C.A., Blazar, B.R., Truitt, R.L. Blood (2002)
- B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Kuchroo, V.K., Das, M.P., Brown, J.A., Ranger, A.M., Zamvil, S.S., Sobel, R.A., Weiner, H.L., Nabavi, N., Glimcher, L.H. Cell (1995)
- Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Dong, H., Strome, S.E., Salomao, D.R., Tamura, H., Hirano, F., Flies, D.B., Roche, P.C., Lu, J., Zhu, G., Tamada, K., Lennon, V.A., Celis, E., Chen, L. Nat. Med. (2002)
- Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. King, C., Mueller Hoenger, R., Malo Cleary, M., Murali-Krishna, K., Ahmed, R., King, E., Sarvetnick, N. Nat. Med. (2001)
- Transport of peptide-MHC class II complexes in developing dendritic cells. Turley, S.J., Inaba, K., Garrett, W.S., Ebersold, M., Unternaehrer, J., Steinman, R.M., Mellman, I. Science (2000)
- CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Yang, Y., Wilson, J.M. Science (1996)
- Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. Reiser, H., Schneeberger, E.E. Eur. J. Immunol. (1996)
- Melphalan and other anticancer modalities up-regulate B7-1 gene expression in tumor cells. Sojka, D.K., Donepudi, M., Bluestone, J.A., Mokyr, M.B. J. Immunol. (2000)
- 4-1BB (CD137) differentially regulates murine in vivo protein- and polysaccharide-specific immunoglobulin isotype responses to Streptococcus pneumoniae. Wu, Z.Q., Khan, A.Q., Shen, Y., Wolcott, K.M., Dawicki, W., Watts, T.H., Mittler, R.S., Snapper, C.M. Infect. Immun. (2003)
- The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Reeves, R.H., Patch, D., Sharpe, A.H., Borriello, F., Freeman, G.J., Edelhoff, S., Disteche, C. Mamm. Genome (1997)
- B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Borriello, F., Sethna, M.P., Boyd, S.D., Schweitzer, A.N., Tivol, E.A., Jacoby, D., Strom, T.B., Simpson, E.M., Freeman, G.J., Sharpe, A.H. Immunity (1997)
- Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. Lenschow, D.J., Sperling, A.I., Cooke, M.P., Freeman, G., Rhee, L., Decker, D.C., Gray, G., Nadler, L.M., Goodnow, C.C., Bluestone, J.A. J. Immunol. (1994)
- Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis. Chang, T.T., Jabs, C., Sobel, R.A., Kuchroo, V.K., Sharpe, A.H. J. Exp. Med. (1999)
- Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody. Vanhove, B., Laflamme, G., Coulon, F., Mougin, M., Vusio, P., Haspot, F., Tiollier, J., Soulillou, J.P. Blood (2003)
- Pancreatic expression of B7 co-stimulatory molecules in the non-obese diabetic mouse. Stephens, L.A., Kay, T.W. Int. Immunol. (1995)
- Microparticulate beta-glucan upregulates the expression of B7.1, B7.2, B7-H1, but not B7-DC on cultured murine peritoneal macrophages. Hunter, K.W., DuPre', S., Redelman, D. Immunol. Lett. (2004)
- Expression of costimulatory molecules: B7 and ICAM up-regulation after treatment with a suicide gene. Ramesh, R., Munshi, A., Abboud, C.N., Marrogi, A.J., Freeman, S.M. Cancer Gene Ther. (1996)
- Induction of costimulatory molecules B7-1 and B7-2 in murine B cells. the CBA/N mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction. Goldstein, M.D., Debenedette, M.A., Hollenbaugh, D., Watts, T.H. Mol. Immunol. (1996)
- The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. Inaba, K., Witmer-Pack, M., Inaba, M., Hathcock, K.S., Sakuta, H., Azuma, M., Yagita, H., Okumura, K., Linsley, P.S., Ikehara, S., Muramatsu, S., Hodes, R.J., Steinman, R.M. J. Exp. Med. (1994)
- Mutational analysis and an alternatively spliced product of B7 defines its CD28/CTLA4-binding site on immunoglobulin C-like domain. Guo, Y., Wu, Y., Zhao, M., Kong, X.P., Liu, Y. J. Exp. Med. (1995)
- CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice. Maletto, B., Rópolo, A., Morón, V., Pistoresi-Palencia, M.C. J. Leukoc. Biol. (2002)
- Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Roy, M., Aruffo, A., Ledbetter, J., Linsley, P., Kehry, M., Noelle, R. Eur. J. Immunol. (1995)
- Limited importance of CD40/CD40L interaction in the B7-dependent generation of anti-MOPC-315 cytotoxic T lymphocyte activity by tumor bearer splenic cells stimulated in vitro in the presence of tumor necrosis factor. Kalinichenko, T.V., Mokyr, M.B. Cancer Immunol. Immunother. (1998)
- B7-1/B7-2 costimulation regulates plaque antigen-specific T-cell responses and atherogenesis in low-density lipoprotein receptor-deficient mice. Buono, C., Pang, H., Uchida, Y., Libby, P., Sharpe, A.H., Lichtman, A.H. Circulation (2004)
- B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. Greenfield, E.A., Howard, E., Paradis, T., Nguyen, K., Benazzo, F., McLean, P., Höllsberg, P., Davis, G., Hafler, D.A., Sharpe, A.H., Freeman, G.J., Kuchroo, V.K. J. Immunol. (1997)
- B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Salomon, B., Lenschow, D.J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A., Bluestone, J.A. Immunity (2000)
- B7-2 requirement for helminth-induced granuloma formation and CD4 type 2 T helper cell cytokine expression. Subramanian, G., Kazura, J.W., Pearlman, E., Jia, X., Malhotra, I., King, C.L. J. Immunol. (1997)
- Upregulation of B7 molecules (CD80 and CD86) and exacerbated eosinophilic pulmonary inflammatory response in mice lacking the IFN-beta gene. Matheu, V., Treschow, A., Navikas, V., Issazadeh-Navikas, S. J. Allergy Clin. Immunol. (2003)
- Interleukin-10 gene transfer to the airway regulates allergic mucosal sensitization in mice. Stämpfli, M.R., Cwiartka, M., Gajewska, B.U., Alvarez, D., Ritz, S.A., Inman, M.D., Xing, Z., Jordana, M. Am. J. Respir. Cell Mol. Biol. (1999)
- Molecular cloning and expression of early T cell costimulatory molecule-1 and its characterization as B7-2 molecule. Chen, C., Gault, A., Shen, L., Nabavi, N. J. Immunol. (1994)
- Differential expression of costimulatory molecules B7-1 and B7-2 on microglial cells induced by Th1 and Th2 cells in organotypic brain tissue. Wolf, S.A., Gimsa, U., Bechmann, I., Nitsch, R. Glia (2001)
- T cells are the main cell type expressing B7-1 and B7-2 in the central nervous system during acute, relapsing and chronic experimental autoimmune encephalomyelitis. Cross, A.H., Lyons, J.A., San, M., Keeling, R.M., Ku, G., Racke, M.K. Eur. J. Immunol. (1999)
- B7/CTLA4 pathway is essential for generating regulatory cells after intratracheal delivery of alloantigen in mice. Akiyama, Y., Shirasugi, N., Uchida, N., Matsumoto, K., Kitajima, M., Bashuda, H., Yagita, H., Okumura, K., Aramaki, O., Niimi, M. Transplantation (2002)