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Gene Review

PFL2510w  -  chitinase

Plasmodium falciparum 3D7

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Disease relevance of PFL2510w


High impact information on PFL2510w

  • Chitinases (EC are critical for parasite invasion of the midgut: the presence of the chitinase inhibitor, allosamidin, in an infectious blood meal prevents oocyst development [1].
  • We used the sequence of PgCHT1 to identify a P. falciparum chitinase gene, PfCHT1, in the P. falciparum genome database [1].
  • In addition, we found that treatment of parasite chitinase with a diisopropyl fluorophosphate-sensitive trypsinlike protease from the mosquito midgut or endoproteinase Lys-C increased its enzymatic activity [2].
  • Using exogenous chitinase, we also found that the PM does not limit the number of parasites that develop into oocysts, suggesting that the parasite produces sufficient quantities of chitinase to penetrate this potential barrier [2].
  • This isolated 35-kDa protein cross-reacted with an antiserum raised against a synthetic peptide derived from the P. gallinaceum chitinase active site, PgCHT1, even though MAb 1C3 did not recognize native or recombinant PgCHT1 on Western blot [3].

Chemical compound and disease context of PFL2510w


Anatomical context of PFL2510w

  • In turn, ookinetes produce multiple chitinase activities presumably aimed at disrupting this physical barrier to allow ookinete invasion of the midgut epithelium [4].


  1. The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences. Vinetz, J.M., Dave, S.K., Specht, C.A., Brameld, K.A., Xu, B., Hayward, R., Fidock, D.A. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. Transmission-blocking activity of a chitinase inhibitor and activation of malarial parasite chitinase by mosquito protease. Shahabuddin, M., Toyoshima, T., Aikawa, M., Kaslow, D.C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  3. Monoclonal antibody against the Plasmodium falciparum chitinase, PfCHT1, recognizes a malaria transmission-blocking epitope in Plasmodium gallinaceum ookinetes unrelated to the chitinase PgCHT1. Langer, R.C., Li, F., Popov, V., Kurosky, A., Vinetz, J.M. Infect. Immun. (2002) [Pubmed]
  4. Knockout of the rodent malaria parasite chitinase pbCHT1 reduces infectivity to mosquitoes. Dessens, J.T., Mendoza, J., Claudianos, C., Vinetz, J.M., Khater, E., Hassard, S., Ranawaka, G.R., Sinden, R.E. Infect. Immun. (2001) [Pubmed]
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