Gene Review:
CHIT1 - chitinase 1 (chitotriosidase)
Homo sapiens
Synonyms:
CHI3, CHIT, CHITD, Chitinase-1, Chitotriosidase-1
Takahashi,
Fujimori,
Miura,
Komatsu,
Nishizawa,
Hibi,
Takamizo,
Ujita,
Sakai,
Hamazaki,
Yoneda,
Isomura,
Hara,
Weber,
Boll,
Stampfl,
van Aalten,
Komander,
Synstad,
Gåseidnes,
Peter,
Eijsink,
Malaguarnera,
Musumeci,
Di Rosa,
Scuto,
Musumeci,
Screen,
Hu,
St Leger,
Gianfrancesco,
Musumeci,
Eiberg,
Den Tandt,
- Polymorphisms of innate immunity genes and susceptibility to lymphatic filariasis. Hise, A.G., Hazlett, F.E., Bockarie, M.J., Zimmerman, P.A., Tisch, D.J., Kazura, J.W. Genes Immun. (2003)
- Genetic polymorphisms of chitotriosidase in Caucasian children with bronchial asthma. Bierbaum, S., Superti-Furga, A., Heinzmann, A. Int. J. Immunogenet. (2006)
- Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Boot, R.G., van Achterberg, T.A., van Aken, B.E., Renkema, G.H., Jacobs, M.J., Aerts, J.M., de Vries, C.J. Arterioscler. Thromb. Vasc. Biol. (1999)
- Molecular cloning, purification, and IgE-binding of a recombinant class I chitinase from Hevea brasiliensis leaves (rHev b 11.0102). Rihs, H.P., Dumont, B., Rozynek, P., Lundberg, M., Cremer, R., Brüning, T., Raulf-Heimsoth, M. Allergy (2003)
- Analysis of chitinase expression in the crayfish plague fungus Aphanomyces astaci. Andersson, M.G., Cerenius, L. Dis. Aquat. Org. (2002)
- Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia. Zhao, X., Tang, R., Gao, B., Shi, Y., Zhou, J., Guo, S., Zhang, J., Wang, Y., Tang, W., Meng, J., Li, S., Wang, H., Ma, G., Lin, C., Xiao, Y., Feng, G., Lin, Z., Zhu, S., Xing, Y., Sang, H., St Clair, D., He, L. Am. J. Hum. Genet. (2007)
- High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: mimicry of carbohydrate substrate. Houston, D.R., Shiomi, K., Arai, N., Omura, S., Peter, M.G., Turberg, A., Synstad, B., Eijsink, V.G., van Aalten, D.M. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Structural insights into the catalytic mechanism of a family 18 exo-chitinase. van Aalten, D.M., Komander, D., Synstad, B., Gåseidnes, S., Peter, M.G., Eijsink, V.G. Proc. Natl. Acad. Sci. U.S.A. (2001)
- The role of enzyme distortion in the single displacement mechanism of family 19 chitinases. Brameld, K.A., Goddard, W.A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Weber, L.W., Boll, M., Stampfl, A. Crit. Rev. Toxicol. (2003)
- Endogenous Nod-factor-like signal molecules promote early somatic embryo development in Norway spruce. Dyachok, J.V., Wiweger, M., Kenne, L., von Arnold, S. Plant Physiol. (2002)
- Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11, a class I chitinase. O'Riordain, G., Radauer, C., Hoffmann-Sommergruber, K., Adhami, F., Peterbauer, C.K., Blanco, C., Godnic-Cvar, J., Scheiner, O., Ebner, C., Breiteneder, H. Clin. Exp. Allergy (2002)
- Shewanella sediminis sp. nov., a novel Na+-requiring and hexahydro-1,3,5-trinitro-1,3,5-triazine-degrading bacterium from marine sediment. Zhao, J.S., Manno, D., Beaulieu, C., Paquet, L., Hawari, J. Int. J. Syst. Evol. Microbiol. (2005)
- Improving macromolecular electrostatics calculations. Nielsen, J.E., Andersen, K.V., Honig, B., Hooft, R.W., Klebe, G., Vriend, G., Wade, R.C. Protein Eng. (1999)
- Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India. Choi, E.H., Zimmerman, P.A., Foster, C.B., Zhu, S., Kumaraswami, V., Nutman, T.B., Chanock, S.J. Genes Immun. (2001)
- Structure of human chitotriosidase. Implications for specific inhibitor design and function of mammalian chitinase-like lectins. Fusetti, F., von Moeller, H., Houston, D., Rozeboom, H.J., Dijkstra, B.W., Boot, R.G., Aerts, J.M., van Aalten, D.M. J. Biol. Chem. (2002)
- Assignment of human plasma methylumbelliferyl-tetra-N-acetylchitotetraoside hydrolase or chitinase to chromosome 1q by a linkage study. Eiberg, H., Den Tandt, W.R. Hum. Genet. (1997)
- Transformants of Metarhizium anisopliae sf. anisopliae overexpressing chitinase from Metarhizium anisopliae sf. acridum show early induction of native chitinase but are not altered in pathogenicity to Manduca sexta. Screen, S.E., Hu, G., St Leger, R.J. J. Invertebr. Pathol. (2001)
- The evolutionary conservation of the human chitotriosidase gene in rodents and primates. Gianfrancesco, F., Musumeci, S. Cytogenet. Genome Res. (2004)
- Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. Hu, B., Trinh, K., Figueira, W.F., Price, P.A. J. Biol. Chem. (1996)
- Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation. Rehli, M., Krause, S.W., Andreesen, R. Genomics (1997)
- Enhanced expression of the human chitinase 3-like 2 gene (YKL-39) but not chitinase 3-like 1 gene (YKL-40) in osteoarthritic cartilage. Steck, E., Breit, S., Breusch, S.J., Axt, M., Richter, W. Biochem. Biophys. Res. Commun. (2002)
- Characterization of ech-42, a Trichoderma harzianum endochitinase gene expressed during mycoparasitism. Carsolio, C., Gutiérrez, A., Jiménez, B., Van Montagu, M., Herrera-Estrella, A. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages. Renkema, G.H., Boot, R.G., Au, F.L., Donker-Koopman, W.E., Strijland, A., Muijsers, A.O., Hrebicek, M., Aerts, J.M. Eur. J. Biochem. (1998)
- Interferon-gamma, tumor necrosis factor-alpha, and lipopolysaccharide promote chitotriosidase gene expression in human macrophages. Malaguarnera, L., Musumeci, M., Di Rosa, M., Scuto, A., Musumeci, S. J. Clin. Lab. Anal. (2005)
- Carbohydrate binding specificity of the recombinant chitin-binding domain of human macrophage chitinase. Ujita, M., Sakai, K., Hamazaki, K., Yoneda, M., Isomura, S., Hara, A. Biosci. Biotechnol. Biochem. (2003)
- Isolation and mapping of a human lung-specific gene, TSA1902, encoding a novel chitinase family member. Saito, A., Ozaki, K., Fujiwara, T., Nakamura, Y., Tanigami, A. Gene (1999)
- Increased resistance to crown rust disease in transgenic Italian ryegrass (Lolium multiflorum Lam.) expressing the rice chitinase gene. Takahashi, W., Fujimori, M., Miura, Y., Komatsu, T., Nishizawa, Y., Hibi, T., Takamizo, T. Plant Cell Rep. (2005)
- Allelic frequency determination of the 24-bp chitotriosidase duplication in the Portuguese population by real-time PCR. Rodrigues, M.R., Sá Miranda, M.C., Amaral, O. Blood Cells Mol. Dis. (2004)
- Ethylene-regulated gene expression: molecular cloning of the genes encoding an endochitinase from Phaseolus vulgaris. Broglie, K.E., Gaynor, J.J., Broglie, R.M. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Screening-based Discovery and Structural Dissection of a Novel Family 18 Chitinase Inhibitor. Schüttelkopf, A.W., Andersen, O.A., Rao, F.V., Allwood, M., Lloyd, C., Eggleston, I.M., van Aalten, D.M. J. Biol. Chem. (2006)