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MeSH Review

Muscle Tonus

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Disease relevance of Muscle Tonus


High impact information on Muscle Tonus

  • Chronically administered 3-nitropropionic acid produces selective lesions in the striatum and reduces muscle tonus [2].
  • At very high doses of haloperidol and later in the action of the drug, muscle tonus appears to be weakened, reducing the likelihood of jumping [3].
  • Muscle tonus was also altered by systemic injections of mephenesin, a centrally acting muscle relaxant [4].
  • Initially described as a peptidergic neuromuscular transmitter, it now appears that proctolin is a major arthropod neurohormone modulating nervous activity, muscle tonus and contractile force [5].
  • The Bi-Digital O-Ring Test, originally developed by Dr. Omura, utilizes changes in the degree of strength of voluntary movements of muscles of the fingers under a definite muscle tonus, making Bi-Digital O-Rings, as an indicator of pathology in the body [6].

Associations of Muscle Tonus with chemical compounds

  • 2. L-glutamate, at a concentration of 10(-4) to 10(-3) M, caused an increase in the frequency of contractions and in muscle tonus [7].
  • Lorazepam induced in this trial a marked relief of anxiety after 60 minutes without changes in vital parameters nor in reflex activity or muscle tonus [8].
  • Increasing the volume of epidural sufentanil, and similarly decreasing the concentration of the injection product, resulted in a potentiation of the analgesic properties of epidural sufentanil without affecting the effects of the drug on the pinna and cornea reflexes and on muscle tonus [9].


  1. Truncal muscle tonus in progressive supranuclear palsy. Tanigawa, A., Komiyama, A., Hasegawa, O. J. Neurol. Neurosurg. Psychiatr. (1998) [Pubmed]
  2. Chronically administered 3-nitropropionic acid produces selective lesions in the striatum and reduces muscle tonus. Shimano, Y., Kumazaki, M., Sakurai, T., Hida, H., Fujimoto, I., Fukuda, A., Nishino, H. Obes. Res. (1995) [Pubmed]
  3. Seemingly paradoxical jumping in cataleptic haloperidol-treated rats is triggered by postural instability. Morrissey, T.K., Pellis, S.M., Pellis, V.C., Teitelbaum, P. Behav. Brain Res. (1989) [Pubmed]
  4. Raphe unit activity in freely moving cats is altered by manipulations of central but not peripheral motor systems. Steinfels, G.F., Heym, J., Strecker, R.E., Jacobs, B.L. Brain Res. (1983) [Pubmed]
  5. Structure function analysis of an arthropod peptide hormone: proctolin and synthetic analogues compared on the cockroach hindgut receptor. Sullivan, R.E., Newcomb, R.W. Peptides (1982) [Pubmed]
  6. The future of the application of the Bi-Digital O-Ring Test in Sports Psychology. Ozerkan, K.N. Acupuncture & electro-therapeutics research. (2005) [Pubmed]
  7. Some pharmacological properties of the oviduct muscularis of the stable fly Stomoxys calcitrans. Cook, B.J., Wagner, R.M. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1992) [Pubmed]
  8. Efficacy of lorazepam oral fast dissolving drug formulation (FDDF) in anesthesia premedication in adults: a double-blind placebo controlled comparison. Van de Velde, A., Camu, F. Acta anaesthesiologica Belgica. (1988) [Pubmed]
  9. Effects of adrenaline, an alpha 2-adrenoceptor agonist, the volume of injection, and the global pain state of the animal on the activity of epidural sufentanil. Meert, T.F., Noorduin, H., Van Craenendonck, H., Vermote, P., Boersma, F.P., Janssen, P.A. Acta anaesthesiologica Belgica. (1989) [Pubmed]
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