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Chemical Compound Review

mephenesin     3-(2-methylphenoxy)propane- 1,2-diol

Synonyms: Curythan, Dioloxal, Dioloxol, Findolar, Findolor, ...
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Disease relevance of mephenesin


Psychiatry related information on mephenesin


High impact information on mephenesin

  • Since GlyRs are involved in motor reflex circuits of the spinal cord and provide inhibitory synapses onto pain sensory neurons, these agents may provide lead compounds for the development of muscle relaxant and peripheral analgesic drugs [11].
  • Administration of a vascular smooth muscle relaxant prevented onset of myocardial necrosis [12].
  • We then studied the smooth-muscle relaxant responses to stimulation by an electrical field and to nitric oxide [13].
  • The muscle relaxant vecuronium is sometimes administered to facilitate mechanical ventilation [14].
  • We report here identification in porcine brain of a novel peptide of 26 amino-acid residues, eliciting a pharmacological spectrum very similar to that of ANP, such as natriuretic-diuretic, hypotensive and chick rectum relaxant activities [15].

Chemical compound and disease context of mephenesin


Biological context of mephenesin


Anatomical context of mephenesin


Associations of mephenesin with other chemical compounds

  • In airway smooth muscle its relaxant action is accompanied by hyperpolarization of the membrane and elevation of the level of intracellular cyclic AMP [31].
  • The smooth muscle relaxant papaverine did not attenuate the response; therefore, such reductions in diameter probably reflect a structural modification of the arterial wall rather than sustained contraction of smooth muscle [32].
  • A characteristic feature of airway smooth muscle is its relative sensitivity to relaxant effects of beta adrenergic agonists when contracted by inflammatory mediators, such as histamine, vs. resistance to these relaxant effects when contracted by muscarinic agonists [33].
  • These data indicate that inflamed lungs are more sensitive to the contractile effects of SP because it is less efficiently degraded by NEP and are less sensitive to the relaxant effects of VIP because it is more efficiently degraded by a tryptic enzyme [34].
  • A possible explanation for the altered diastolic pressure-volume relationships with nitroprusside might be a direct relaxant effect of nitroprusside on ventricular muscle, similar to its known relaxant effect on vascular smooth muscle [35].

Gene context of mephenesin


Analytical, diagnostic and therapeutic context of mephenesin

  • The longitudinal smooth muscle layer of the guinea pig ileum, where neurotensin has both a direct relaxant and an indirect contractile action, has been used extensively as a biological assay system for neurotensin [41].
  • No significant difference was observed among the CABGs with different duration of transplantation, whereas the relaxant responses of different segments along the entire length of a CABG were markedly different [42].
  • Exposure to NOLA at 10 mumol/l reduced stimulation-induced relaxations; this reduction was significantly greater in tissues from the diabetic group than from the control group (p < 0.05), probably as a consequence of the smaller relaxant responses in muscles from diabetic rats [43].
  • Proximal left circumflex vessels exposed to ischaemia and reperfusion showed enhanced sensitivity to the relaxant effects of SIN-1 compared to control proximal vessels obtained from the same hearts [44].
  • A series of 2-[( alkoxycarbonyl )amino]-4(5)-phenyl-2-imidazolines was prepared and evaluated for central nervous system (CNS) effects (antidepressant, anticonvulsant, muscle relaxant, and depressant) in animal models [45].


  1. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., Narumiya, S. Nature (1997) [Pubmed]
  2. Cyclobenzaprine in intractable pain syndromes with muscle spasm. Brown, B.R., Womble, J. JAMA (1978) [Pubmed]
  3. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. Adnot, S., Raffestin, B., Eddahibi, S., Braquet, P., Chabrier, P.E. J. Clin. Invest. (1991) [Pubmed]
  4. Medical management of urinary incontinence. Diokno, A.C. Gastroenterology (2004) [Pubmed]
  5. G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling. Kuschel, M., Zhou, Y.Y., Cheng, H., Zhang, S.J., Chen, Y., Lakatta, E.G., Xiao, R.P. J. Biol. Chem. (1999) [Pubmed]
  6. Does treatment with clean intermittent catheterization in boys with posterior urethral valves affect bladder and renal function? Holmdahl, G., Sillen, U., Hellström, A.L., Sixt, R., Sölsnes, E. J. Urol. (2003) [Pubmed]
  7. Long-term abecarnil administration produces tolerance and withdrawal signs in the rat. Elliot, E.E., White, J.M. Eur. J. Pharmacol. (2000) [Pubmed]
  8. An intrasubject comparison of two doses of succinylcholine in modified electroconvulsive therapy. Murali, N., Saravanan, E.S., Ramesh, V.J., Gangadhar, B.N., Jananakiramiah, N., Kumar, S.S., Christopher, R., Subbakrishna, D.K. Anesth. Analg. (1999) [Pubmed]
  9. Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice. Büyükafşar, K., Un, I. Eur. J. Pharmacol. (2003) [Pubmed]
  10. Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza. Lee, C.M., Wong, H.N., Chui, K.Y., Choang, T.F., Hon, P.M., Chang, H.M. Neurosci. Lett. (1991) [Pubmed]
  11. Molecular structure and function of the glycine receptor chloride channel. Lynch, J.W. Physiol. Rev. (2004) [Pubmed]
  12. Disruption of the sarcoglycan-sarcospan complex in vascular smooth muscle: a novel mechanism for cardiomyopathy and muscular dystrophy. Coral-Vazquez, R., Cohn, R.D., Moore, S.A., Hill, J.A., Weiss, R.M., Davisson, R.L., Straub, V., Barresi, R., Bansal, D., Hrstka, R.F., Williamson, R., Campbell, K.P. Cell (1999) [Pubmed]
  13. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. Rajfer, J., Aronson, W.J., Bush, P.A., Dorey, F.J., Ignarro, L.J. N. Engl. J. Med. (1992) [Pubmed]
  14. Persistent paralysis in critically ill patients after long-term administration of vecuronium. Segredo, V., Caldwell, J.E., Matthay, M.A., Sharma, M.L., Gruenke, L.D., Miller, R.D. N. Engl. J. Med. (1992) [Pubmed]
  15. A new natriuretic peptide in porcine brain. Sudoh, T., Kangawa, K., Minamino, N., Matsuo, H. Nature (1988) [Pubmed]
  16. Superoxide generation and reversal of acetylcholine-induced cerebral arteriolar dilation after acute hypertension. Wei, E.P., Kontos, H.A., Christman, C.W., DeWitt, D.S., Povlishock, J.T. Circ. Res. (1985) [Pubmed]
  17. Enhanced release of endothelium-derived relaxing factor in mineralocorticoid hypertension. Bockman, C.S., Jeffries, W.B., Pettinger, W.A., Abel, P.W. Hypertension (1992) [Pubmed]
  18. Relaxation of vascular smooth muscle by isoproterenol, dibutyryl-cyclic AMP and theophylline. Webb, R.C., Bohr, D.F. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  19. Adenosine A(2A) receptors in portal hypertension: their role in the abnormal response to adenosine of the cranial mesenteric artery in rabbits. de Brito, M.T., Canto, A., Correia, J.H., Cunha, R.A., Marques, M.C. Br. J. Pharmacol. (2002) [Pubmed]
  20. Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. Dumas, M., Dumas, J.P., Rochette, L., Advenier, C., Giudicelli, J.F. Br. J. Pharmacol. (1996) [Pubmed]
  21. Bioactive cardiac substances: potent vasorelaxant activity in mammalian atria. Currie, M.G., Geller, D.M., Cole, B.R., Boylan, J.G., YuSheng, W., Holmberg, S.W., Needleman, P. Science (1983) [Pubmed]
  22. Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass. Wessel, D.L., Adatia, I., Giglia, T.M., Thompson, J.E., Kulik, T.J. Circulation (1993) [Pubmed]
  23. Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. de Graaf, J.C., Banga, J.D., Moncada, S., Palmer, R.M., de Groot, P.G., Sixma, J.J. Circulation (1992) [Pubmed]
  24. Myosin phosphorylation and cyclic adenosine 3',5'-monophosphate in relaxation of arterial smooth muscle by vasodilators. Gerthoffer, W.T., Trevethick, M.A., Murphy, R.A. Circ. Res. (1984) [Pubmed]
  25. Substance P-induced pulmonary vasoreactivity in isolated perfused guinea pig lung. Selig, W.M., Burhop, K.E., Garcia, J.G., Malik, A.B. Circ. Res. (1988) [Pubmed]
  26. Increases in cyclic GMP levels may not mediate relaxant effects of sodium nitroprusside, verapamil and hydralazine in rat vas deferens. Diamond, J., Janis, R.A. Nature (1978) [Pubmed]
  27. Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways. Matsuzaki, Y., Hamasaki, Y., Said, S.I. Science (1980) [Pubmed]
  28. Calcium release from skeletal muscle sarcoplasmic reticulum: site of action of dantrolene sodium. Van Winkle, W.B. Science (1976) [Pubmed]
  29. Effects of histamine receptor stimulation on diseased gallbladder and cystic duct. Lennon, F., Feeley, T.M., Clanachan, A.S., Scott, G.W. Gastroenterology (1984) [Pubmed]
  30. Measurement of human esophageal tone in vivo. Mayrand, S., Diamant, N.E. Gastroenterology (1993) [Pubmed]
  31. Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation. Kume, H., Takai, A., Tokuno, H., Tomita, T. Nature (1989) [Pubmed]
  32. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium-dependent. Langille, B.L., O'Donnell, F. Science (1986) [Pubmed]
  33. Differential inhibitory effects of forskolin, isoproterenol, and dibutyryl cyclic adenosine monophosphate on phosphoinositide hydrolysis in canine tracheal smooth muscle. Madison, J.M., Brown, J.K. J. Clin. Invest. (1988) [Pubmed]
  34. Effects of chronic airway inflammation on the activity and enzymatic inactivation of neuropeptides in guinea pig lungs. Lilly, C.M., Kobzik, L., Hall, A.E., Drazen, J.M. J. Clin. Invest. (1994) [Pubmed]
  35. Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations. Brodie, B.R., Grossman, W., Mann, T., McLaurin, L.P. J. Clin. Invest. (1977) [Pubmed]
  36. Parathyroid hormone-related protein relaxes rat gastric smooth muscle and shows cross-desensitization with parathyroid hormone. Mok, L.L., Ajiwe, E., Martin, T.J., Thompson, J.C., Cooper, C.W. J. Bone Miner. Res. (1989) [Pubmed]
  37. Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice. Dick, J.M., Van Molle, W., Brouckaert, P., Lefebvre, R.A. J. Physiol. (Lond.) (2002) [Pubmed]
  38. Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus. Manzini, S. Br. J. Pharmacol. (1992) [Pubmed]
  39. Lipopolysaccharide Induces Epithelium- and Prostaglandin E2-Dependent Relaxation of Mouse Isolated Trachea through Activation of Cyclooxygenase (COX)-1 and COX-2. Balzary, R.W., Cocks, T.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  40. Cytochrome P-450 expression in sudden infant death syndrome. Treluyer, J.M., Cheron, G., Sonnier, M., Cresteil, T. Biochem. Pharmacol. (1996) [Pubmed]
  41. Evidence for neurotensin as a non-adrenergic, non-cholinergic neurotransmitter in guinea pig ileum. Goedert, M., Hunter, J.C., Ninkovic, M. Nature (1984) [Pubmed]
  42. Endothelium-dependent responses in long-term human coronary artery bypass grafts. Ku, D.D., Caulfield, J.B., Kirklin, J.K. Circulation (1991) [Pubmed]
  43. Nitric oxide-mediated neurotransmission is attenuated in the anococcygeus muscle from diabetic rats. Way, K.J., Reid, J.J. Diabetologia (1994) [Pubmed]
  44. Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or inhibition of nitric oxide synthesis. Coughlan, M.G., Kenny, D., Kampine, J.P., Bosnjak, Z.J., Warltier, D.C. Cardiovasc. Res. (1993) [Pubmed]
  45. Synthesis and central nervous system properties of 2-[(alkoxycarbonyl)amino]-4(5)-phenyl-2-imidazolines. Weinhardt, K., Beard, C.C., Dvorak, C., Marx, M., Patterson, J., Roszkowski, A., Schuler, M., Unger, S.H., Wagner, P.J., Wallach, M.B. J. Med. Chem. (1984) [Pubmed]
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