Disease relevance of Alcoholic Neuropathy

• Other neurotoxic effects of alcohol with cognitive impairments include delirium tremens, alcoholic seizures or "rum fits," and alcoholic neuropathies [1].

High impact information on Alcoholic Neuropathy

• Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy [2].
• Sensory-dominant involvement with prominent neuropathic pain is characteristic of alcoholic neuropathy when thiamine deficiency is not involved, supporting the view of direct neurotoxic effect by alcohol or its metabolites [3].
• Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans [4].
• Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study) [5].
• The results confirm that ethanol plays a definitive role in the development of alcoholic neuropathy and that malnutrition accentuates, the histopathological abnormalities [6].

Chemical compound and disease context of Alcoholic Neuropathy

• Benfotiamine led to significant improvement of alcoholic polyneuropathy [5].
• Sympathetic vasoconstrictor nerve function in alcoholic neuropathy [7].
• Mexiletine for painful alcoholic neuropathy [8].
• Finally the patient was diagnosed with methanol poisoning complicated by both loss of vision and severe alcoholic polyneuropathy [9].

Gene context of Alcoholic Neuropathy

• A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy, BAP I) [5].

References