Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

MeSH Review:

Alcohol Withdrawal Seizures

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Alcohol Withdrawal Seizures

We studied the hormonal responses to a generalized tonic-clonic convulsion in 20 patients with idiopathic or posttraumatic epilepsy (6 patients) or alcohol-withdrawal seizures (14 patients) [1].

Psychiatry related information on Alcohol Withdrawal Seizures

The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure [2].
The findings indicate that coadministration of amphetamine and fenfluramine, a treatment effective in reducing alcohol withdrawal seizures, also selectively attenuates alcohol consumption [3].

High impact information on Alcohol Withdrawal Seizures

CONCLUSION: When administered to non-epileptic patients within six hours of the onset of alcohol withdrawal seizures, intravenous diphenylhydantoin failed to show a significant benefit over placebo in the prevention of subsequent seizures [4].
Furthermore, it has been shown that high homocysteine levels predicted first-onset alcohol withdrawal seizures [5].
The aim of the current experiment was to investigate the consequences of repeated withdrawal from ethanol on amphetamine-induced behaviours in the rat and compare this with animals with electrical kindling of the amygdala, a procedure that has been shown to enhance alcohol withdrawal seizures [Pinel et al. (1975) Can. J. Neurol. Sci., 2, 467-475] [6].
Enhancement of alcohol withdrawal seizures with 6-hydroxydopamine [7].
Following a 9-h withdrawal period from the alcohol-containing diet, phentermine enhanced the effects of 5-HTP on both reduction of alcohol withdrawal seizures as well as changes in striatal serotonin [8].

Chemical compound and disease context of Alcohol Withdrawal Seizures

Collectively, these findings show that coadministered phentermine plus 5-HTP is effective in reducing alcohol intake and suppressing alcohol withdrawal seizures [8].
Lorazepam to prevent alcohol withdrawal seizures [9].
Chlormethiazole is a positive modulator of gamma-aminobutyric acid (GABA)(A) receptors used in the treatment of alcohol withdrawal seizures [10].
Taking into account that homocysteine and its breakdown products (i.e. homocysteic acid) are putative neurotransmitters and agonists at the NMDA receptor, the aim of this study was to assess the influence of levels of homocysteine on alcohol withdrawal seizures [11].
We report a case of prolonged coma (7 days) which arose as a complication of the treatment of alcohol withdrawal seizures and delirium with intravenous phenobarbital and diazepam [12].

Biological context of Alcohol Withdrawal Seizures

Genotypes of the Cys23Ser polymorphism were assessed in 454 subjects of German descent, comprising: 1) 93 severely affected alcohol-dependent males with a history of alcohol withdrawal seizure or delirium, 2) 119 patients affected by an idiopathic generalized epilepsy, and 3) 242 controls [13].

Anatomical context of Alcohol Withdrawal Seizures

These mouse disorders include audiogenic seizures, the epilepsy (El) mutation, spontaneous seizures, the tottering/learner syndrome, cerebellar abnormalities, myelin disorders, and alcohol withdrawal seizures [14].

Gene context of Alcohol Withdrawal Seizures

We conclude that in patients with alcohol-induced hyperhomocysteinaemia the KFM is a useful tool to predict alcohol withdrawal seizures [15].

References

The hormonal responses to generalized tonic-clonic seizures. Aminoff, M.J., Simon, R.P., Wiedemann, E. Brain (1984) [Pubmed]
The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol-withdrawal seizure. Gorwood, P., Limosin, F., Batel, P., Hamon, M., Adès, J., Boni, C. Biol. Psychiatry (2003) [Pubmed]
Amphetamine and fenfluramine suppress ethanol intake in ethanol-dependent rats. Yu, Y.L., Fisher, H., Sekowski, A., Wagner, G.C. Alcohol (1997) [Pubmed]
Placebo-controlled trial of intravenous diphenylhydantoin for short-term treatment of alcohol withdrawal seizures. Alldredge, B.K., Lowenstein, D.H., Simon, R.P. Am. J. Med. (1989) [Pubmed]
Alcoholism-associated hyperhomocysteinemia and previous withdrawal seizures. Bayerlein, K., Hillemacher, T., Reulbach, U., Mugele, B., Sperling, W., Kornhuber, J., Bleich, S. Biol. Psychiatry (2005) [Pubmed]
Consequences of amygdala kindling and repeated withdrawal from ethanol on amphetamine-induced behaviours. Ripley, T.L., Dunworth, S.J., Stephens, D.N. Eur. J. Neurosci. (2002) [Pubmed]
Enhancement of alcohol withdrawal seizures with 6-hydroxydopamine. Chu, N.S. Epilepsia (1978) [Pubmed]
Alterations in alcohol consumption, withdrawal seizures, and monoamine transmission in rats treated with phentermine and 5-hydroxy-L-tryptophan. Halladay, A.K., Wagner, G.C., Sekowski, A., Rothman, R.B., Baumann, M.H., Fisher, H. Synapse (2006) [Pubmed]
Lorazepam to prevent alcohol withdrawal seizures. Seidl, J.J., Layde, P. The Journal of family practice. (1999) [Pubmed]
Chlormethiazole potentiates the discriminative stimulus effects of methamphetamine in rats. Gasior, M., Witkin, J.M., Goldberg, S.R., Munzar, P. Eur. J. Pharmacol. (2004) [Pubmed]
Plasma homocysteine is a predictor of alcohol withdrawal seizures. Bleich, S., Degner, D., Bandelow, B., von Ahsen, N., Rüther, E., Kornhuber, J. Neuroreport (2000) [Pubmed]
Reduction of diazepam serum half life and reversal of coma by activated charcoal in a patient with severe liver disease. Traeger, S.M., Haug, M.T. J. Toxicol. Clin. Toxicol. (1986) [Pubmed]
Association analysis between a Cys23Ser substitution polymorphism of the human 5-HT2c receptor gene and neuronal hyperexcitability. Samochowiec, J., Smolka, M., Winterer, G., Rommelspacher, H., Schmidt, L.G., Sander, T. Am. J. Med. Genet. (1999) [Pubmed]
A review of mouse mutants as genetic models of epilepsy. Seyfried, T.N., Glaser, G.H. Epilepsia (1985) [Pubmed]
Risk assessment of alcohol withdrawal seizures with a Kohonen feature map. Kurth, C., Wegerer, V., Degner, D., Sperling, W., Kornhuber, J., Paulus, W., Bleich, S. Neuroreport (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.