The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Skin Irritancy Tests

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Skin Irritancy Tests

  • Using mannitol as a reference compound, penetration profiles and epidermal distribution similar to those obtained with human skin ex vivo were obtained both with EpiDerm and Episkin [1].
  • Compared with native epidermis and RE-DED in EpiDerm, SkinEthic and Episkin models, the content of polar ceramides 5 and 6 was lower, ceramide 7 was absent, and the content of free fatty acids was very low [2].
  • The present study aimed at evaluating the influence on caffeine's and alpha-tocopherol's cutaneous bioavailability of cosmetic vehicles such as a water-in-oil emulsion, an oil-in-water emulsion, a liposome dispersion and a hydrogel applied at finite dose using the reconstructed human skin models EpiDerm and Episkin [3].
  • Improved protocols and PMs for the EpiDerm and EPISKIN methods, the pig ear test, and the SIFT were presented at an extended Task Force meeting held in May 2001 [4].
  • The reproducibility of 3 industrial models--EpiDerm, Episkin and SkinEthic--was tested regarding the permeation and skin absorption of 3 topically applied compounds (with a large range of physicochemical properties): lauric acid, caffeine and mannitol [5].

Associations of Skin Irritancy Tests with chemical compounds

  • The MTT viability results showed that EpiDerm was the most resistant to the SLS treatment and at the same time the most reproducible model, SkinEthic was the most sensitive to SLS and the least reproducible, and Episkin and the Cosmital model were intermediate [6].


  1. Improvement of the experimental setup to assess cutaneous bioavailability on human skin models: dynamic protocol. Dreher, F., Patouillet, C., Fouchard, F., Zanini, M., Messager, A., Roguet, R., Cottin, M., Leclaire, J., Benech-Kieffer, F. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
  2. Characterization of reconstructed skin models. Ponec, M., Boelsma, E., Gibbs, S., Mommaas, M. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
  3. Comparison of cutaneous bioavailability of cosmetic preparations containing caffeine or alpha-tocopherol applied on human skin models or human skin ex vivo at finite doses. Dreher, F., Fouchard, F., Patouillet, C., Andrian, M., Simonnet, J.T., Benech-Kieffer, F. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
  4. Follow-up to the ECVAM prevalidation study on in vitro tests for acute skin irritation. The European Centre for the Validation of Alternative Methods Skin Irritation Task Force report 2. Zuang, V., Balls, M., Botham, P.A., Coquette, A., Corsini, E., Curren, R.D., Elliott, G.R., Fentem, J.H., Heylings, J.R., Liebsch, M., Medina, J., Roguet, R., van de Sandt, J.J., Wiemann, C., Worth, A.P. Alternatives to laboratory animals : ATLA. (2002) [Pubmed]
  5. Permeation and skin absorption: reproducibility of various industrial reconstructed human skin models. Lotte, C., Patouillet, C., Zanini, M., Messager, A., Roguet, R. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
  6. Reconstructed skin kits: reproducibility of cutaneous irritancy testing. Faller, C., Bracher, M. Skin Pharmacol. Appl. Skin Physiol. (2002) [Pubmed]
WikiGenes - Universities