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Chemical Compound Review

laurate     dodecanoic acid

Synonyms: vulvate, dodecylate, Dodecanoate, Laurinsaeure, laurostearate, ...
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Disease relevance of lauric acid


High impact information on lauric acid

  • Spectra of albumin complexes with the 12-carbon saturated fatty acid, lauric acid, had several narrow laurate carboxyl peaks at 35 degrees C, indicating longer lifetimes (tau much greater than 66 msec) in the different binding sites [6].
  • Similarly, DCs treated with lauric acid show increased T cell activation capacity, whereas docosahexaenoic acid inhibits T cell activation induced by LPS-treated DCs [7].
  • Together, these results demonstrate that lauric acid activates TLR2 dimers as well as TLR4 for which respective bacterial agonists require acylated fatty acids, whereas DHA inhibits the activation of all TLRs tested [8].
  • However, neither lauric acid nor DHA affected the heterodimerization of TLR2 with TLR6 as well as the homodimerization of TLR4 as determined by co-immunoprecipitation assays in 293T cells in which these TLRs were transiently overexpressed [8].
  • Using D-erythro-sphingosine and lauric acid as substrates, the reaction followed normal Michaelis-Menten kinetics [9].

Chemical compound and disease context of lauric acid


Biological context of lauric acid


Anatomical context of lauric acid


Associations of lauric acid with other chemical compounds


Gene context of lauric acid

  • These results demonstrate that NFkappaB activation and COX-2 expression induced by lauric acid are at least partly mediated through the TLR4/PI3K/AKT signaling pathway [29].
  • In contrast, COX-2 expression by TLR2 or TRL4 agonist was potentiated by lauric acid, a saturated fatty acid [30].
  • Human CYP2E1 had the highest lauric acid (omega-1)-hydroxylation activity and also had catalytic properties similar to those of rat CYP2E1 [31].
  • Results of docking of a common substrate, lauric acid, into the binding site of both CYP4A11 and CYP102 and molecular dynamics simulations provided additional support for this hypothesis [32].
  • Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation [33].

Analytical, diagnostic and therapeutic context of lauric acid


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  33. Drosophila melanogaster CYP6A8, an insect P450 that catalyzes lauric acid (omega-1)-hydroxylation. Helvig, C., Tijet, N., Feyereisen, R., Walker, F.A., Restifo, L.L. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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