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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Leeching

 
 
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Disease relevance of Leeching

  • The possibility of sensitizing patients to heparin leeching from a HBG with the activation of platelets and secondary thrombosis strongly suggests that HBG be used with great caution [1].
  • PATIENTS: 51 patients with osteoarthritis of the knee (leech therapy: 24 patients, mean age [+/-SD], 62.5 +/- 10.2 years; topical diclofenac therapy: 27 patients, mean age [+/-SD], 65.5 +/- 6.7 years) [2].
 

High impact information on Leeching

  • Leeching out the intracellular calcium stores abolished the effect of 17beta-estradiol on NO release [3].
  • It is hypothesised that high NO levels during GTN infusion may decrease the detectable superoxide due to "leeching" of the superoxide into low level peroxynitrite formation [4].
  • MAIN OUTCOME MEASURES: Flap salvage rate, number of leeches used per patient, time needed for inosculation, duration of intensive care unit admission, transfusion requirement per patient, and complications during leech therapy [5].
  • CONCLUSION: Leeching added to conventional treatment of SLE could be more effective in improving the level of plasma ET and sIL-2R, and ameliorating the impairment of renal tissues [6].
  • Leech therapy for complicated varicose veins [7].
 

Associations of Leeching with chemical compounds

  • RESULTS: The primary end point, pain at day 7, was reduced from a mean (+/-SD) of 53.5 +/- 13.7 to 19.3 +/- 12.2 after leech therapy compared with 51.5 +/- 16.8 to 42.4 +/- 19.7 with topical diclofenac (estimated group difference, -23.9 [95% CI, -32.8 to -15.1]; P < 0.001) [2].
  • The use of a styrofoam cup in leeching replanted digits [8].
  • Porous carbonaceous adsorbent was prepared by carbonization of saccharose in silica gel pores followed by leeching out of the silica matrix [9].
 

Analytical, diagnostic and therapeutic context of Leeching

  • METHODS: Forty-four patients with SLE were randomly divided into conventional corticosteroid treated group (control group, n = 20) and conventional treatment group with leeching intervention added (leeching group, n = 24) [6].

References

  1. Heparin-bonded grafts induce platelet aggregation in the presence of heparin-associated antiplatelet antibodies. Almeida, J.I., Liem, T.K., Silver, D. J. Vasc. Surg. (1998) [Pubmed]
  2. Effectiveness of leech therapy in osteoarthritis of the knee: a randomized, controlled trial. Michalsen, A., Klotz, S., Lüdtke, R., Moebus, S., Spahn, G., Dobos, G.J. Ann. Intern. Med. (2003) [Pubmed]
  3. Estradiol coupling to human monocyte nitric oxide release is dependent on intracellular calcium transients: evidence for an estrogen surface receptor. Stefano, G.B., Prevot, V., Beauvillain, J.C., Fimiani, C., Welters, I., Cadet, P., Breton, C., Pestel, J., Salzet, M., Bilfinger, T.V. J. Immunol. (1999) [Pubmed]
  4. Effects of sumatriptan on nitric oxide and superoxide balance during glyceryl trinitrate infusion in the rat. Implications for antimigraine mechanisms. Read, S.J., Manning, P., McNeil, C.J., Hunter, A.J., Parsons, A.A. Brain Res. (1999) [Pubmed]
  5. Leech therapy for patients with surgically unsalvageable venous obstruction after revascularized free tissue transfer. Chepeha, D.B., Nussenbaum, B., Bradford, C.R., Teknos, T.N. Arch. Otolaryngol. Head Neck Surg. (2002) [Pubmed]
  6. Study of the effect of leeching on plasma endothelin and soluble interleukin-2 receptor in patients with systemic lupus erythematosus. Cheng, S.P., Liu, J.L., Yuan, J. Chinese journal of integrative medicine. (2005) [Pubmed]
  7. Leech therapy for complicated varicose veins. Bapat, R.D., Acharya, B.S., Juvekar, S., Dahanukar, S.A. Indian J. Med. Res. (1998) [Pubmed]
  8. The use of a styrofoam cup in leeching replanted digits. al-Qattan, M.M., Zuker, R.M. British journal of plastic surgery. (1993) [Pubmed]
  9. Use of porous pyrolytic carbon for analytical and microscale high-performance liquid chromatographic bioseparations. Petro, M., Belliardo, F., Novák, I., Berek, D. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
 
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