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MeSH Review:

Pulsatilla

Liu, W.K. et al., Mimaki, Y. et al., Ekabo, O.A. et al., Bang, S.C. et al., Lee, H.S., et al.

Steinsbekk, Bentzen, Fønnebø, Lewith, Nikolova, Asenov, Lee,

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Disease relevance of Pulsatilla

Seventeen saponins isolated from the root of Pulsatilla koreana were examined for their in vitro cytotoxic activity against the human solid cancer cell lines, A-549, SK-OV-3, SK-MEL-2, and HCT15, using the SRB assay method, and their in vivo antitumor activity using BDF1 mice bearing Lewis lung carcinoma (LLC) [1].

High impact information on Pulsatilla

We present here the apoptotic activity of several natural derivatives of betulinic acid which were isolated from the roots of a Chinese medicinal herb, Pulsatilla chinensis (Bge) Regel [Ye, W., Ji, N.N., Zhao, S.X., Liu, J.H., Ye, T., McKervey, M.A., Stevenson, P., 1996. Triterpenoids from Pulsatilla chinensis. Phytochemistry 42, 799-802] [2].
Protoanemonin, the lactone of gamma-hydroxy-vinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi [3].
Triterpenoid saponins from the roots of Pulsatilla koreana [4].
The inhibition of mushroom tyrosinase by Pulsatilla cernua root-derived materials was evaluated [5].
The bioactive components of Pulsatilla cernua root were characterized by spectroscopic analyses as 3,4-dihydroxycinnamic acid and 4-hydroxy-3-methoxycinnamic acid, which exhibited potent antityrosinase activity [5].

Associations of Pulsatilla with chemical compounds

Two known saponins, pulsatilla saponin D (3-O-[[beta-D- glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-alpha-L- arabinopyranosyl] hederagenin) (1) and 3-O-[[beta-D-glucopyranosyl-(1-->4)]-[alpha-L-rhamnopyranosyl-(1-->2)]-a lpha-L- arabinopyranosyl] oleanolic acid (2) were also isolated from this plant [6].
Two new triterpene saponins (8 and 9) and seven previously reported triterpene saponins (1-7) based upon oleanolic acid or hederagenin, along with two known lignans, (+)-pinoresinol (10) and beta-peltatin (11), were isolated from a saponin fraction prepared from the MeOH extract of the roots of Pulsatilla chinensis [7].
RESULT: By using simplified constitutional indications for the three most commonly prescribed remedies, Calcarea carb, Pulsatilla and Sulphur, parents were able to choose the same homeopathic medicine as homeopaths' prescribed for 55% (95% CI 43-67) of children with URTI [8].
This is the first report for the presence on external flavonoid aglycones in genus Pulsatilla [9].

Gene context of Pulsatilla

Chemiluminescence detection of superoxide anion release and superoxide dismutase activity: modulation effect of Pulsatilla chinensis [10].

References

Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship. Bang, S.C., Lee, J.H., Song, G.Y., Kim, D.H., Yoon, M.Y., Ahn, B.Z. Chem. Pharm. Bull. (2005) [Pubmed]
Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line. Liu, W.K., Ho, J.C., Cheung, F.W., Liu, B.P., Ye, W.C., Che, C.T. Eur. J. Pharmacol. (2004) [Pubmed]
In vitro activity of protoanemonin, an antifungal agent. Martín, M.L., San Román, L., Domínguez, A. Planta Med. (1990) [Pubmed]
Triterpenoid saponins from the roots of Pulsatilla koreana. Bang, S.C., Kim, Y., Lee, J.H., Ahn, B.Z. J. Nat. Prod. (2005) [Pubmed]
Tyrosinase inhibitors of Pulsatilla cernua root-derived materials. Lee, H.S. J. Agric. Food Chem. (2002) [Pubmed]
Antifungal and molluscicidal saponins from Serjania salzmanniana. Ekabo, O.A., Farnsworth, N.R., Henderson, T.O., Mao, G., Mukherjee, R. J. Nat. Prod. (1996) [Pubmed]
Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. Mimaki, Y., Kuroda, M., Asano, T., Sashida, Y. J. Nat. Prod. (1999) [Pubmed]
The use of simplified constitutional indications for self-prescription of homeopathic medicine. Steinsbekk, A., Bentzen, N., Fønnebø, V., Lewith, G. Complementary therapies in medicine. (2004) [Pubmed]
Surface flavonoid aglycones in newly studied plant species. Nikolova, M., Asenov, A. Nat. Prod. Res. (2006) [Pubmed]
Chemiluminescence detection of superoxide anion release and superoxide dismutase activity: modulation effect of Pulsatilla chinensis. Yao, D., Vlessidis, A.G., Gou, Y., Zhou, X., Zhou, Y., Evmiridis, N.P. Analytical and bioanalytical chemistry. (2004) [Pubmed]

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