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MeSH Review:

Sinomenium

Kok, T.W. et al., Kim, H.M. et al., Yamasaki, H., Liu, B. et al., Jiang, M. et al., et al.

Kim, Moon, Chae, Kim, Chung, Kim, Lee, Liu, Jiang, Shen, Chang,

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Disease relevance of Sinomenium

The aqueous extract of Sinomenium acutum stem (SSAE) (0.1-1000 mg/kg) dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice [1].

High impact information on Sinomenium

Supercritical carbon dioxide, with and without a methanol modifier, was used to extract sinomenine from Sinomenium acutum (Thumb) Rehd et Wils [2].
Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum [3].
Sinomenine is an alkaloid extracted from the Chinese medicinal plant, Sinomenium acutum, which has been utilized to treat rheumatoid arthritis (RA) in China for over 2000 years [4].
Rash was often associated with D-penicillamine (20.6%) and Sinomenium therapy (13.7%) [5].
The anti-rheumatic effect on Sinomenium acutum are probably genuine and can probably be attributed to the histamine-releasing properties of sinomenine [6].

References

The stem of sinomenium acutum inhibits mast cell-mediated anaphylactic reactions and tumor necrosis factor-alpha production from rat peritoneal mast cells. Kim, H.M., Moon, P.D., Chae, H.J., Kim, H.R., Chung, J.G., Kim, J.J., Lee, E.J. Journal of ethnopharmacology. (2000) [Pubmed]
Supercritical fluid extraction of sinomenine from Sinomenium acutum (Thumb) Rehd et Wils. Liu, B., Jiang, H., Shen, B., Chang, Y. Journal of chromatography. A. (2005) [Pubmed]
Isolation of lipolytic substances caffeine and 1,7-dimethylxanthine from the stem and rhizome of Sinomenium actum. Jiang, M., Kameda, K., Han, L.K., Kimura, Y., Okuda, H. Planta Med. (1998) [Pubmed]
The anti-angiogenic effect of sinomenine. Kok, T.W., Yue, P.Y., Mak, N.K., Fan, T.P., Liu, L., Wong, R.N. Angiogenesis (2005) [Pubmed]
Retrospective study of adverse events in patients with rheumatoid arthritis treated with second-line drugs. Jiang, L., Zhao, N., Ni, L. Zhonghua Liu Xing Bing Xue Za Zhi (2002) [Pubmed]
Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Yamasaki, H. Acta Med. Okayama (1976) [Pubmed]

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