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Chemical Compound Review

paraxanthine     1,7-dimethyl-3H-purine-2,6- dione

Synonyms: p-Xanthine, Lopac-D-5385, CHEMBL1158, PubChem23157, SureCN232702, ...
 
 
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Disease relevance of p-Xanthine

 

Psychiatry related information on p-Xanthine

 

High impact information on p-Xanthine

 

Chemical compound and disease context of p-Xanthine

 

Biological context of p-Xanthine

 

Anatomical context of p-Xanthine

 

Associations of p-Xanthine with other chemical compounds

 

Gene context of p-Xanthine

 

Analytical, diagnostic and therapeutic context of p-Xanthine

References

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  14. Analysis of within-subject variation of caffeine metabolism when used to determine cytochrome P4501A2 and N-acetyltransferase-2 activities. McQuilkin, S.H., Nierenberg, D.W., Bresnick, E. Cancer Epidemiol. Biomarkers Prev. (1995) [Pubmed]
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  17. Paraxanthine, a caffeine metabolite, dose dependently increases [Ca(2+)](i) in skeletal muscle. Hawke, T.J., Allen, D.G., Lindinger, M.I. J. Appl. Physiol. (2000) [Pubmed]
  18. Paraxanthine displaces the binding of [3H]SCH 23390 from rat striatal membranes. Ferré, S., Guix, T., Sallés, J., Badia, A., Parra, P., Jané, F., Herrera-Marschitz, M., Ungerstedt, U., Casas, M. Eur. J. Pharmacol. (1990) [Pubmed]
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  20. Four-week treatment with omeprazole increases the metabolism of caffeine. Nousbaum, J.B., Berthou, F., Carlhant, D., Riche, C., Robaszkiewicz, M., Gouerou, H. Am. J. Gastroenterol. (1994) [Pubmed]
  21. Determination of theophylline in serum and saliva in the presence of caffeine and its metabolites. Moncrieff, J. J. Chromatogr. (1991) [Pubmed]
  22. Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine. Sachse, C., Brockmöller, J., Bauer, S., Roots, I. British journal of clinical pharmacology. (1999) [Pubmed]
  23. In vivo effect of clarithromycin on multiple cytochrome P450s. Bruce, M.A., Hall, S.D., Haehner-Daniels, B.D., Gorski, J.C. Drug Metab. Dispos. (2001) [Pubmed]
  24. Effect of interferon alpha-ribavirin bitherapy on cytochrome P450 1A2 and 2D6 and N-acetyltransferase-2 activities in patients with chronic active hepatitis C. Becquemont, L., Chazouilleres, O., Serfaty, L., Poirier, J.M., Broly, F., Jaillon, P., Poupon, R., Funck-Brentano, C. Clin. Pharmacol. Ther. (2002) [Pubmed]
  25. CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Nowell, S., Sweeney, C., Hammons, G., Kadlubar, F.F., Lang, N.P. Cancer Epidemiol. Biomarkers Prev. (2002) [Pubmed]
  26. Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice. Casley, W.L., Menzies, J.A., Whitehouse, L.W., Moon, T.W. Drug Metab. Dispos. (1999) [Pubmed]
  27. Caffeine, estradiol, and progesterone interact with human CYP1A1 and CYP1A2. Evidence from cDNA-directed expression in Saccharomyces cerevisiae. Eugster, H.P., Probst, M., Würgler, F.E., Sengstag, C. Drug Metab. Dispos. (1993) [Pubmed]
  28. Orientation of caffeine within the active site of human cytochrome P450 1A2 based on NMR longitudinal (T1) relaxation measurements. Regal, K.A., Nelson, S.D. Arch. Biochem. Biophys. (2000) [Pubmed]
  29. Simple and reliable CYP1A2 phenotyping by the paraxanthine/caffeine ratio in plasma and in saliva. Fuhr, U., Rost, K.L. Pharmacogenetics (1994) [Pubmed]
  30. Evaluation of chromatographic and kit immunoassay techniques for the measurement of theophylline in serum: a study based on external quality assurance measurements. Wilson, J.F., Williams, J., Tsanaclis, L.M., Tedstone, J.E., Richens, A. Therapeutic drug monitoring. (1988) [Pubmed]
  31. K+ transport in resting rat hind-limb skeletal muscle in response to paraxanthine, a caffeine metabolite. Hawke, T.J., Willmets, R.G., Lindinger, M.I. Can. J. Physiol. Pharmacol. (1999) [Pubmed]
  32. Caffeine and its dimethylxanthine metabolites in two cases of caffeine overdose: a cause of falsely elevated theophylline concentrations in serum. Fligner, C.L., Opheim, K.E. Journal of analytical toxicology. (1988) [Pubmed]
  33. Development of a biosensor for caffeine. Babu, V.R., Patra, S., Karanth, N.G., Kumar, M.A., Thakur, M.S. Anal. Chim. Acta (2007) [Pubmed]
 
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