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MeSH Review:

Hydrastis

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Disease relevance of Hydrastis

The root extracts of goldenseal (Hydrastis canadensis L.) are popular phytomedicines for the treatment of gastrointestinal disorders and upper respiratory tract infections [1].

High impact information on Hydrastis

RESULTS: Comparisons of presupplementation and postsupplementation phenotypic ratio means revealed significant inhibition (approximately 40%) of CYP2D6 (difference, -0.228; 95% confidence interval [CI], -0.268 to -0.188) and CYP3A4/5 (difference, -1.501; 95% CI, -1.840 to -1.163) activity for goldenseal [2].
Accordingly, serious adverse interactions may result from the concomitant ingestion of goldenseal supplements and drugs that are CYP2D6 and CYP3A4/5 substrates [2].
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes [2].
Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components [3].
Influence of goldenseal root on the pharmacokinetics of indinavir [4].

Associations of Hydrastis with chemical compounds

Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine [5].
Neochlorogenic acid (9), which has not previously been reported from goldenseal, and chlorogenic acid (6) reached their highest levels in leaves (0.9% 9 and 0.5% 6) [6].
Minimal or selective interferences were seen with golden seal tea lemon juice, Visine, and low concentrations of bleach and Drano [7].
These studies suggest that bearberry, golden seal, mistletoe and tarragon may counter some of the symptoms of streptozotocin diabetes without, however, affecting glycemic control [8].

Gene context of Hydrastis

BACKGROUND: Goldenseal (Hydrastis canadensis L) is a multi-purpose herb (Hobbs, 1990: Pharm Hist 32:79-82) widely used for its antibiotic properties [9].

Analytical, diagnostic and therapeutic context of Hydrastis

A fast, practical ambient extraction methodology followed by isocratic liquid chromatography (LC) analysis with UV detection was validated for the determination of berberine, hydrastine, and canadine in goldenseal (Hydrastis canadensis L.) root powder [10].

References

Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts. Unger, M., Laug, S., Holzgrabe, U. Electrophoresis (2005) [Pubmed]
In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Khan, I.A., Shah, A. Clin. Pharmacol. Ther. (2005) [Pubmed]
Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Chatterjee, P., Franklin, M.R. Drug Metab. Dispos. (2003) [Pubmed]
Influence of goldenseal root on the pharmacokinetics of indinavir. Sandhu, R.S., Prescilla, R.P., Simonelli, T.M., Edwards, D.J. Journal of clinical pharmacology. (2003) [Pubmed]
Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. Inbaraj, J.J., Kukielczak, B.M., Bilski, P., Sandvik, S.L., Chignell, C.F. Chem. Res. Toxicol. (2001) [Pubmed]
A new glucosyl feruloyl quinic acid as a potential marker for roots and rhizomes of goldenseal, Hydrastis canadensis. McNamara, C.E., Perry, N.B., Follett, J.M., Parmenter, G.A., Douglas, J.A. J. Nat. Prod. (2004) [Pubmed]
CEDIA for screening drugs of abuse in urine and the effect of adulterants. Wu, A.H., Forte, E., Casella, G., Sun, K., Hemphill, G., Foery, R., Schanzenbach, H. J. Forensic Sci. (1995) [Pubmed]
Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Swanston-Flatt, S.K., Day, C., Bailey, C.J., Flatt, P.R. Acta diabetologica latina. (1989) [Pubmed]
A reproductive screening test of goldenseal. Yao, M., Ritchie, H.E., Brown-Woodman, P.D. Birth Defects Res. B Dev. Reprod. Toxicol. (2005) [Pubmed]
Method validation for determination of alkaloid content in goldenseal root powder. Weber, H.A., Zart, M.K., Hodges, A.E., White, K.D., Barnes, S.M., Moody, L.A., Clark, A.P., Harris, R.K., Overstreet, J.D., Smith, C.S. Journal of AOAC International. (2003) [Pubmed]

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