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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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High impact information on Blighia

  • Methylene blue and fatal encephalopathy from ackee fruit poisoning [1].
  • Glycine in ackee poisoning [2].
  • Pig kidney general acyl-CoA dehydrogenase is irreversibly inactivated by methylenecyclopropylacetyl-CoA, a metabolite of the hypoglycemic amino acid hypoglycin from Blighia sapida, to less that 2% of native activity [3].
  • The utility of this methodology was demonstrated by the concise synthesis of a protected homoserine equivalent, alpha-azidobutyro lactone, and a naturally occurring alpha-amino acid from the seeds of Blighia unijugata [4].
  • Early glucose and methylene blue are effective against unripe ackee apple (Blighia sapida) poisoning in mice [5].

Biological context of Blighia


Anatomical context of Blighia


Associations of Blighia with chemical compounds

  • In conclusion, considering the high lethality of the ackee apple intoxication, the total absence of any existing treatment and the safety of glucose administration, we recommend at this stage to use early sugar or glucose administration in the field, in addition to a specific population-based prevention programme [5].
  • Because ackee poisoning has certain biochemical similarities to ifosfamide encephalopathy, we evaluated the efficacy of methylene blue (MB) and glucose (G), alone and in combination (MB+G) in mice, as a treatment for ackee poisoning [5].
  • Cocaine and ackee were each implicated in two (9%) cases [8].


  1. Methylene blue and fatal encephalopathy from ackee fruit poisoning. Küpfer, A., Idle, J.R. Lancet (1999) [Pubmed]
  2. Glycine in ackee poisoning. Sherratt, H.S., Al-Bassam, S.S. Lancet (1977) [Pubmed]
  3. Inactivation of general acyl-CoA dehydrogenase from pig kidney by a metabolite of hypoglycin A. Wenz, A., Thorpe, C., Ghisla, S. J. Biol. Chem. (1981) [Pubmed]
  4. A beta-lactone route to chiral gamma-substituted alpha-amino acids: application to the concise synthesis of (S)-alpha-azidobutyro lactone and a natural amino acid. Tennyson, R.L., Cortez, G.S., Galicia, H.J., Kreiman, C.R., Thompson, C.M., Romo, D. Org. Lett. (2002) [Pubmed]
  5. Early glucose and methylene blue are effective against unripe ackee apple (Blighia sapida) poisoning in mice. Barennes, H., Valea, I., Boudat, A.M., Idle, J.R., Nagot, N. Food Chem. Toxicol. (2004) [Pubmed]
  6. Jamaican vomiting sickness: a study of two adult cases. Golden, K.D., Kean, E.A., Terry, S.I. Clin. Chim. Acta (1984) [Pubmed]
  7. Selective inhibition of acyl-CoA dehydrogenases by a metabolite of hypoglycin. Kean, E.A. Biochim. Biophys. Acta (1976) [Pubmed]
  8. Fatal poisoning in Jamaica: a coroner's autopsy study from the University Hospital of the West Indies. Escoffery, C.T., Shirley, S.E. Medicine, science, and the law. (2004) [Pubmed]
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