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Chemical Compound Review

HYPOGLYCIN     2-amino-3-(2- methylidenecyclopropyl) propan...

Synonyms: Hypoglycine, Hypoglycine A, Hypoglycin A, AGN-PC-00FS19, SureCN956162, ...
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Disease relevance of HYPOGLYCIN

  • Pesticide toxicity or hypoglycine A poisoning (Ivory Coast, 1984) [1]?
  • 2. Injection of hypoglycin into fasted rats maintained on a standard diet caused severe prostration, hypothermia and a massive dicarboxylic aciduria [Tanaka (1972) J. Biol. Chem. 247, 7465-7478] [2].
  • Results showed that, although hypoglycin A induced severe hypoglycemia after intravenous application, there was no significant change in insulin levels [3].
  • 4-Pentenoic acid, an analog of hypoglycin which is believed to cause Jamaican vomiting sickness, was administered intraperitoneally to rats in an attempt to produce the features of Reye's syndrome in rats [4].

High impact information on HYPOGLYCIN


Chemical compound and disease context of HYPOGLYCIN


Biological context of HYPOGLYCIN


Anatomical context of HYPOGLYCIN


Associations of HYPOGLYCIN with other chemical compounds


Analytical, diagnostic and therapeutic context of HYPOGLYCIN

  • Numerous abnormal metabolites were identified in large amounts in the urine of hypoglycin-treated rats using capillary gas chromatography/mass spectrometry-computer analysis [16].


  1. Pesticide toxicity or hypoglycine A poisoning (Ivory Coast, 1984)? Brun, T. Lancet (1988) [Pubmed]
  2. Organic aciduria in rats made resistant to hypoglycin toxicity by pretreatment with clofibrate. Veitch, R.K., Sherratt, H.S., Bartlett, K. Biochem. J. (1987) [Pubmed]
  3. Effect of hypoglycin A on insulin release. Mills, J., Melville, G.N., Bennett, C., West, M., Castro, A. Biochem. Pharmacol. (1987) [Pubmed]
  4. Production of the features of Reye's syndrome in rats with 4-pentenoic acid. Glasgow, A.M., Chase, H.P. Pediatr. Res. (1975) [Pubmed]
  5. Inhibition of gluconeogenesis by hypoglycin: alternate interpretations. Tanaka, K. Hepatology (1987) [Pubmed]
  6. Inhibition of gluconeogenesis by hypoglycin in the rat. Evidence for inhibition of glucose-6-phosphatase in vivo. Hue, L., Sherratt, H.S. Biochem. J. (1986) [Pubmed]
  7. Protection of rats by clofibrate against the hypoglycaemic and toxic effects of hypoglycin and pent-4-enoate. An ultrastructural and biochemical study. Van Hoof, F., Hue, L., Vamecq, J., Sherratt, H.S. Biochem. J. (1985) [Pubmed]
  8. Mechanisms of the metabolic disturbances caused by hypoglycin and by pent-4-enoic acid. In vitro studies. Billington, D., Osmundsen, H., Sherratt, H.S. Biochem. Pharmacol. (1978) [Pubmed]
  9. The antagonism of the toxicity of hypoglycin by glycine. Al-Bassam, S.S., Sherratt, H.S. Biochem. Pharmacol. (1981) [Pubmed]
  10. Ackee (Blighia sapida) hypoglycin A toxicity: dose response assessment in laboratory rats. Blake, O.A., Bennink, M.R., Jackson, J.C. Food Chem. Toxicol. (2006) [Pubmed]
  11. Jamaican vomiting sickness: a study of two adult cases. Golden, K.D., Kean, E.A., Terry, S.I. Clin. Chim. Acta (1984) [Pubmed]
  12. The biogenesis of dicarboxylic acid in rats given hypoglycin. Golden, K.D., Kean, E.A. Biochim. Biophys. Acta (1984) [Pubmed]
  13. Selective inhibition of acyl-CoA dehydrogenases by a metabolite of hypoglycin. Kean, E.A. Biochim. Biophys. Acta (1976) [Pubmed]
  14. Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin). Kean, E.A., Pogson, C.I. Biochem. J. (1979) [Pubmed]
  15. Defective imino acid metabolism in hypoglycin-treated rats. Goodman, S.I., Valle, D. Biochemical medicine. (1984) [Pubmed]
  16. Capillary gas chromatographic/mass spectrometric analysis of abnormal metabolites in hypoglycin-treated rat urine. Hine, D.G., Tanaka, K. Biomed. Mass Spectrom. (1984) [Pubmed]
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