Gene Review:
Adrbk1 - adrenergic receptor kinase, beta 1
Mus musculus
Synonyms:
Adrbk-1, Bark-1, Beta-ARK-1, Beta-adrenergic receptor kinase 1, G-protein-coupled receptor kinase 2, ...
- Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. Keys, J.R., Greene, E.A., Cooper, C.J., Naga Prasad, S.V., Rockman, H.A., Koch, W.J. Am. J. Physiol. Heart Circ. Physiol. (2003)
- Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. Koch, W.J., Rockman, H.A. Trends Cardiovasc. Med. (1999)
- Cloning of GRK2 cDNA from S49 murine lymphoma cells. Hughes, R.J., Anderson, K.L., Kiel, D., Insel, P.A. Am. J. Physiol. (1996)
- Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Eckhart, A.D., Duncan, S.J., Penn, R.B., Benovic, J.L., Lefkowitz, R.J., Koch, W.J. Circ. Res. (2000)
- G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. Vroon, A., Kavelaars, A., Limmroth, V., Lombardi, M.S., Goebel, M.U., Van Dam, A.M., Caron, M.G., Schedlowski, M., Heijnen, C.J. J. Immunol. (2005)
- Structure of the pleckstrin homology domain from beta-spectrin. Macias, M.J., Musacchio, A., Ponstingl, H., Nilges, M., Saraste, M., Oschkinat, H. Nature (1994)
- Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Koch, W.J., Rockman, H.A., Samama, P., Hamilton, R.A., Bond, R.A., Milano, C.A., Lefkowitz, R.J. Science (1995)
- Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. Perrino, C., Naga Prasad, S.V., Mao, L., Noma, T., Yan, Z., Kim, H.S., Smithies, O., Rockman, H.A. J. Clin. Invest. (2006)
- Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. Freeman, K., Lerman, I., Kranias, E.G., Bohlmeyer, T., Bristow, M.R., Lefkowitz, R.J., Iaccarino, G., Koch, W.J., Leinwand, L.A. J. Clin. Invest. (2001)
- Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. Mayor, F., Benovic, J.L., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1987)
- Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. Iaccarino, G., Keys, J.R., Rapacciuolo, A., Shotwell, K.F., Lefkowitz, R.J., Rockman, H.A., Koch, W.J. J. Am. Coll. Cardiol. (2001)
- Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells. Luo, X., Zeng, W., Xu, X., Popov, S., Davignon, I., Wilkie, T.M., Mumby, S.M., Muallem, S. J. Biol. Chem. (1999)
- Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Iaccarino, G., Dolber, P.C., Lefkowitz, R.J., Koch, W.J. Hypertension (1999)
- Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Rockman, H.A., Chien, K.R., Choi, D.J., Iaccarino, G., Hunter, J.J., Ross, J., Lefkowitz, R.J., Koch, W.J. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. Perrino, C., Naga Prasad, S.V., Patel, M., Wolf, M.J., Rockman, H.A. J. Am. Coll. Cardiol. (2005)
- Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4. Vroon, A., Heijnen, C.J., Lombardi, M.S., Cobelens, P.M., Mayor, F., Caron, M.G., Kavelaars, A. J. Leukoc. Biol. (2004)
- Cellular and functional defects in a mouse model of heart failure. Esposito, G., Santana, L.F., Dilly, K., Cruz, J.D., Mao, L., Lederer, W.J., Rockman, H.A. Am. J. Physiol. Heart Circ. Physiol. (2000)
- Beta-arrestin mediates desensitization and internalization but does not affect dephosphorylation of the thyrotropin-releasing hormone receptor. Jones, B.W., Hinkle, P.M. J. Biol. Chem. (2005)
- GRK2 is an endogenous protein inhibitor of the insulin signaling pathway for glucose transport stimulation. Usui, I., Imamura, T., Satoh, H., Huang, J., Babendure, J.L., Hupfeld, C.J., Olefsky, J.M. EMBO J. (2004)
- Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. Rockman, H.A., Choi, D.J., Akhter, S.A., Jaber, M., Giros, B., Lefkowitz, R.J., Caron, M.G., Koch, W.J. J. Biol. Chem. (1998)
- Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. Cho, M.C., Rao, M., Koch, W.J., Thomas, S.A., Palmiter, R.D., Rockman, H.A. Circulation (1999)
- Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Iaccarino, G., Tomhave, E.D., Lefkowitz, R.J., Koch, W.J. Circulation (1998)
- GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. Shahid, G., Hussain, T. J. Biol. Chem. (2007)
- Norepinephrine- and epinephrine-induced distinct beta2-adrenoceptor signaling is dictated by GRK2 phosphorylation in cardiomyocytes. Wang, Y., De Arcangelis, V., Gao, X., Ramani, B., Jung, Y.S., Xiang, Y. J. Biol. Chem. (2008)
- A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization. Mundell, S.J., Benovic, J.L., Kelly, E. Mol. Pharmacol. (1997)
- Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. Benovic, J.L., Onorato, J.J., Arriza, J.L., Stone, W.C., Lohse, M., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1991)
- Agonist activated adrenocorticotropin receptor internalizes via a clathrin-mediated G protein receptor kinase dependent mechanism. Baig, A.H., Swords, F.M., Szaszák, M., King, P.J., Hunyady, L., Clark, A.J. Endocr. Res. (2002)
- Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor signaling and increases resting blood pressure. Eckhart, A.D., Ozaki, T., Tevaearai, H., Rockman, H.A., Koch, W.J. Mol. Pharmacol. (2002)
- In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Akhter, S.A., Eckhart, A.D., Rockman, H.A., Shotwell, K., Lefkowitz, R.J., Koch, W.J. Circulation (1999)
- Treatment with inverse agonists enhances baseline atrial contractility in transgenic mice with chronic beta2-adrenoceptor activation. Nagaraja, S., Iyer, S., Liu, X., Eichberg, J., Bond, R.A. Br. J. Pharmacol. (1999)
- Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor. Benovic, J.L., Strasser, R.H., Caron, M.G., Lefkowitz, R.J. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Antidiabetic effect of novel modulating peptides of G-protein-coupled kinase in experimental models of diabetes. Anis, Y., Leshem, O., Reuveni, H., Wexler, I., Ben Sasson, R., Yahalom, B., Laster, M., Raz, I., Ben Sasson, S., Shafrir, E., Ziv, E. Diabetologia (2004)