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Gene Review

ADRA2C  -  adrenoceptor alpha 2C

Homo sapiens

Synonyms: ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR, Alpha-2 adrenergic receptor subtype C4, ...
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Disease relevance of ADRA2C

  • Sequence variations in the human alpha2 adrenergic receptor genes (ADRA2A and ADRA2C) have been implicated as a cause of hypertension in blacks [1].
  • The alpha 2-adrenoceptors of the human retinoblastoma cell line (Y79) may represent an additional example of the alpha 2C-adrenoceptor [2].

High impact information on ADRA2C


Biological context of ADRA2C


Anatomical context of ADRA2C


Associations of ADRA2C with chemical compounds


Other interactions of ADRA2C

  • Three genes encode alpha2-AR subtypes carrying common functional polymorphisms (ADRA2A Asn251Lys, ADRA2B Ins/Del301-303 and ADRA2C Ins/Del322-325) [8].
  • These findings exclude a strong effect of this ADRA2C marker on risk for ADHD in our sample of adult proband families [20].
  • The investigation of families carrying recombinant chromosomes, pulsed-field analysis, and genomic walking mapped the ADRA2C gene adjacent to D4S81, 500 kb proximal to the HD gene [9].

Analytical, diagnostic and therapeutic context of ADRA2C


  1. Do allelic variants in alpha2A and alpha2C adrenergic receptors predispose to hypertension in blacks? Li, J.L., Canham, R.M., Vongpatanasin, W., Leonard, D., Auchus, R.J., Victor, R.G. Hypertension (2006) [Pubmed]
  2. The alpha 2-adrenoceptors of the human retinoblastoma cell line (Y79) may represent an additional example of the alpha 2C-adrenoceptor. Gleason, M.M., Hieble, J.P. Br. J. Pharmacol. (1992) [Pubmed]
  3. The palmitoylated cysteine of the cytoplasmic tail of alpha 2A-adrenergic receptors confers subtype-specific agonist-promoted downregulation. Eason, M.G., Jacinto, M.T., Theiss, C.T., Liggett, S.B. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  4. Cell-type specific targeting of the alpha 2c-adrenoceptor. Evidence for the organization of receptor microdomains during neuronal differentiation of PC12 cells. Hurt, C.M., Feng, F.Y., Kobilka, B. J. Biol. Chem. (2000) [Pubmed]
  5. Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go. Coupry, I., Duzic, E., Lanier, S.M. J. Biol. Chem. (1992) [Pubmed]
  6. Attention-deficit hyperactivity disorder and the adrenergic receptors alpha 1C and alpha 2C. Barr, C.L., Wigg, K., Zai, G., Roberts, W., Malone, M., Schachar, R., Tannock, R., Kennedy, J.L. Mol. Psychiatry (2001) [Pubmed]
  7. An in-frame deletion in the alpha(2C) adrenergic receptor is common in African--Americans. Feng, J., Zheng, J., Gelernter, J., Kranzler, H., Cook, E., Goldman, D., Jones, I.R., Craddock, N., Heston, L.L., Delisi, L., Peltonen, L., Bennett, W.P., Sommer, S.S. Mol. Psychiatry (2001) [Pubmed]
  8. Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene. Belfer, I., Buzas, B., Hipp, H., Phillips, G., Taubman, J., Lorincz, I., Evans, C., Lipsky, R.H., Enoch, M.A., Max, M.B., Goldman, D. J. Hum. Genet. (2005) [Pubmed]
  9. Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16. Riess, O., Thies, U., Siedlaczck, I., Potisek, S., Graham, R., Theilmann, J., Grimm, T., Epplen, J.T., Hayden, M.R. Genomics (1994) [Pubmed]
  10. Identification of a naturally occurring 21 bp deletion in alpha 2c noradrenergic receptor gene and cognitive correlates to antipsychotic treatment. De Luca, V., Vincent, J.B., Müller, D.J., Hwang, R., Shinkai, T., Volavka, J., Czobor, P., Sheitman, B.B., Lindenmayer, J.P., Citrome, L., McEvoy, J.P., Lieberman, J.A., Kennedy, J.L. Pharmacol. Res. (2005) [Pubmed]
  11. Heterologous expression of the cloned guinea pig alpha 2A, alpha 2B, and alpha 2C adrenoceptor subtypes. Radioligand binding and functional coupling to a CAMP-responsive reporter gene. Svensson, S.P., Bailey, T.J., Porter, A.C., Richman, J.G., Regan, J.W. Biochem. Pharmacol. (1996) [Pubmed]
  12. Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Schambra, U.B., Mackensen, G.B., Stafford-Smith, M., Haines, D.E., Schwinn, D.A. Neuroscience (2005) [Pubmed]
  13. alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. Smith, M.S., Schambra, U.B., Wilson, K.H., Page, S.O., Hulette, C., Light, A.R., Schwinn, D.A. Brain Res. Mol. Brain Res. (1995) [Pubmed]
  14. Cloning and expression of the alpha 2C-adrenergic receptor from the OK cell line. Blaxall, H.S., Cerutis, D.R., Hass, N.A., Iversen, L.J., Bylund, D.B. Mol. Pharmacol. (1994) [Pubmed]
  15. Distribution of alpha 2A- and alpha 2C-adrenergic receptor immunoreactivity in the central nervous system. Rosin, D.L. Methods Mol. Biol. (2000) [Pubmed]
  16. Comparison of ligand binding affinities at human I1-imidazoline binding sites and the high affinity state of alpha-2 adrenoceptor subtypes. Piletz, J.E., Zhu, H., Chikkala, D.N. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  17. A linkage study with D5 dopamine and alpha 2C-adrenergic receptor genes in six multiplex bipolar pedigrees. Byerley, W., Hoff, M., Holik, J., Coon, H. Psychiatr. Genet. (1994) [Pubmed]
  18. Characterization of lacZ complementation deletions using membrane receptor dimerization. Thormeyer, D., Ammerpohl, O., Larsson, O., Xu, Y., Asinger, A., Wahlestedt, C., Liang, Z. BioTechniques (2003) [Pubmed]
  19. Down-regulation of the alpha-2C adrenergic receptor: involvement of a serine/threonine motif in the third cytoplasmic loop. Deupree, J.D., Borgeson, C.D., Bylund, D.B. BMC Pharmacol. (2002) [Pubmed]
  20. Adrenergic alpha 2C receptor genomic organization: association study in adult ADHD. De Luca, V., Muglia, P., Vincent, J.B., Lanktree, M., Jain, U., Kennedy, J.L. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2004) [Pubmed]
  21. Assignment of two alpha 2 adrenoceptor subtype genes to murine chromosomes. Chang, N.C., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Chang, Y.H., Chen, W.M., Chang, A.C. Neurosci. Lett. (1994) [Pubmed]
  22. Perikaryal and synaptic localization of alpha 2A-adrenergic receptor-like immunoreactivity. Aoki, C., Go, C.G., Venkatesan, C., Kurose, H. Brain Res. (1994) [Pubmed]
  23. Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression. Neumeister, A., Drevets, W.C., Belfer, I., Luckenbaugh, D.A., Henry, S., Bonne, O., Herscovitch, P., Goldman, D., Charney, D.S. Neuropsychopharmacology (2006) [Pubmed]
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